IL18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0070328Biological processtriglyceride homeostasis
GO_0032722Biological processpositive regulation of chemokine production
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_0001525Biological processangiogenesis
GO_0042092Biological processtype 2 immune response
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_2000556Biological processpositive regulation of T-helper 1 cell cytokine production
GO_0006954Biological processinflammatory response
GO_0008283Biological processcell population proliferation
GO_0061436Biological processestablishment of skin barrier
GO_0030431Biological processsleep
GO_0032819Biological processpositive regulation of natural killer cell proliferation
GO_0045662Biological processnegative regulation of myoblast differentiation
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0032736Biological processpositive regulation of interleukin-13 production
GO_0030101Biological processnatural killer cell activation
GO_0034105Biological processpositive regulation of tissue remodeling
GO_0007267Biological processcell-cell signaling
GO_0042632Biological processcholesterol homeostasis
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0042088Biological processT-helper 1 type immune response
GO_0032725Biological processpositive regulation of granulocyte macrophage colony-stimulating factor production
GO_0051142Biological processpositive regulation of NK T cell proliferation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0035655Biological processinterleukin-18-mediated signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0032729Biological processpositive regulation of type II interferon production
GO_0150078Biological processpositive regulation of neuroinflammatory response
GO_0050729Biological processpositive regulation of inflammatory response
GO_0030155Biological processregulation of cell adhesion
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0042119Biological processneutrophil activation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0045630Biological processpositive regulation of T-helper 2 cell differentiation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005829Cellular componentcytosol
GO_0045515Molecular functioninterleukin-18 receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL18
Protein nameInterleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
Interleukin-18 (IL-18)
SynonymsIL1F4
IGIF
DescriptionFUNCTION: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses . Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators . Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells . Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore . .

FUNCTION: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. .

AccessionsENST00000524595.5 [Q14116-2]
ENST00000280357.12 [Q14116-1]
B0YJ28
ENST00000528832.1 [Q14116-1]
Q14116