I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 7 studies | 36% ± 19% | |
| fibroblast | 6 studies | 38% ± 12% | |
| endothelial cell | 4 studies | 37% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 7 studies | 36% ± 19% | |
| fibroblast | 6 studies | 38% ± 12% | |
| endothelial cell | 4 studies | 37% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| kidney | 4 studies | 22% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 99% | 3413.13 | 88 / 89 | 94% | 17.85 | 849 / 901 |
| breast | 87% | 506.76 | 399 / 459 | 85% | 6.38 | 948 / 1118 |
| thymus | 78% | 286.86 | 509 / 653 | 61% | 3.37 | 370 / 605 |
| uterus | 90% | 545.32 | 153 / 170 | 28% | 1.32 | 130 / 459 |
| lung | 63% | 169.61 | 364 / 578 | 54% | 2.65 | 626 / 1155 |
| blood vessel | 100% | 2742.87 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 96% | 819.28 | 1154 / 1204 | 0% | 0 | 0 / 0 |
| skin | 37% | 117.16 | 673 / 1809 | 54% | 6.07 | 253 / 472 |
| pancreas | 1% | 4.09 | 4 / 328 | 78% | 5.98 | 139 / 178 |
| bladder | 48% | 176.81 | 10 / 21 | 29% | 1.34 | 144 / 504 |
| esophagus | 41% | 152.12 | 590 / 1445 | 34% | 1.44 | 62 / 183 |
| heart | 73% | 478.18 | 625 / 861 | 0% | 0 | 0 / 0 |
| ovary | 24% | 52.56 | 44 / 180 | 48% | 4.44 | 206 / 430 |
| prostate | 37% | 107.34 | 91 / 245 | 23% | 0.81 | 115 / 502 |
| intestine | 33% | 88.46 | 322 / 966 | 23% | 1.15 | 120 / 527 |
| stomach | 14% | 29.78 | 51 / 359 | 33% | 1.34 | 94 / 286 |
| muscle | 36% | 97.68 | 288 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 33% | 1.57 | 15 / 45 |
| brain | 2% | 3.72 | 60 / 2642 | 28% | 1.46 | 194 / 705 |
| adrenal gland | 1% | 1.50 | 2 / 258 | 19% | 0.82 | 43 / 230 |
| eye | 0% | 0 | 0 / 0 | 14% | 0.47 | 11 / 80 |
| liver | 0% | 0 | 0 / 226 | 6% | 0.25 | 26 / 406 |
| spleen | 6% | 12.11 | 15 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.12 | 1 / 29 |
| peripheral blood | 0% | 0.45 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0071333 | Biological process | cellular response to glucose stimulus |
| GO_0006954 | Biological process | inflammatory response |
| GO_0042554 | Biological process | superoxide anion generation |
| GO_0055007 | Biological process | cardiac muscle cell differentiation |
| GO_1903409 | Biological process | reactive oxygen species biosynthetic process |
| GO_2000573 | Biological process | positive regulation of DNA biosynthetic process |
| GO_0003015 | Biological process | heart process |
| GO_0050667 | Biological process | homocysteine metabolic process |
| GO_0045453 | Biological process | bone resorption |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0010467 | Biological process | gene expression |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0006801 | Biological process | superoxide metabolic process |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0061098 | Biological process | positive regulation of protein tyrosine kinase activity |
| GO_0006952 | Biological process | defense response |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0097038 | Cellular component | perinuclear endoplasmic reticulum |
| GO_0043020 | Cellular component | NADPH oxidase complex |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005634 | Cellular component | nucleus |
| GO_0106292 | Molecular function | superoxide-generating NADPH oxidase activity |
| GO_0050660 | Molecular function | flavin adenine dinucleotide binding |
| GO_0009055 | Molecular function | electron transfer activity |
| GO_0019826 | Molecular function | oxygen sensor activity |
| GO_0106294 | Molecular function | NADPH oxidase H202-forming activity |
| GO_1990782 | Molecular function | protein tyrosine kinase binding |
| GO_0000166 | Molecular function | nucleotide binding |
| GO_0016174 | Molecular function | NAD(P)H oxidase H2O2-forming activity |
| GO_0020037 | Molecular function | heme binding |
| GO_0072341 | Molecular function | modified amino acid binding |
| GO_0016175 | Molecular function | superoxide-generating NAD(P)H oxidase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NOX4 |
| Protein name | NADPH oxidase 4 (EC 1.6.3.1) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase) NADPH oxidase 4 |
| Synonyms | RENOX |
| Description | FUNCTION: NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 . Can also catalyze to a smaller extent, the reduction of oxygen to superoxide . May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity . May regulate insulin signaling cascade . May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB . May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation . .; FUNCTION: [Isoform 4]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor . Involved in redox signaling in vascular cells . Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage . .; FUNCTION: [Isoform 3]: Lacks superoxide-generating NADPH oxidase activity. . |
| Accessions | ENST00000534731.5 [Q9NPH5-6] ENST00000527626.5 E9PR43 ENST00000529343.5 [Q9NPH5-5] ENST00000263317.9 [Q9NPH5-1] ENST00000343727.9 [Q9NPH5-8] ENST00000424319.5 [Q9NPH5-8] ENST00000531342.5 [Q9NPH5-3] E9PI95 ENST00000525196.5 ENST00000393282.2 [Q9NPH5-7] ENST00000527956.5 [Q9NPH5-8] E9PPP2 ENST00000375979.7 [Q9NPH5-4] ENST00000532825.5 [Q9NPH5-9] ENST00000528341.5 Q9NPH5 |
