I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| dendritic cell | 7 studies | 35% ± 9% | |
| fibroblast | 6 studies | 31% ± 23% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| dendritic cell | 7 studies | 35% ± 9% | |
| fibroblast | 6 studies | 31% ± 23% |
Insufficient scRNA-seq data for expression of CCL19 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 87% | 1072.54 | 401 / 459 | 64% | 93.39 | 710 / 1118 |
| lung | 74% | 1253.11 | 429 / 578 | 75% | 101.09 | 863 / 1155 |
| prostate | 66% | 868.95 | 162 / 245 | 69% | 48.32 | 344 / 502 |
| thymus | 83% | 1412.83 | 541 / 653 | 42% | 203.78 | 255 / 605 |
| liver | 78% | 644.31 | 176 / 226 | 34% | 58.86 | 138 / 406 |
| skin | 51% | 437.09 | 919 / 1809 | 56% | 124.71 | 263 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 1136.20 | 29 / 29 |
| pancreas | 15% | 57.73 | 49 / 328 | 72% | 149.85 | 128 / 178 |
| esophagus | 53% | 605.62 | 764 / 1445 | 26% | 19.94 | 47 / 183 |
| bladder | 43% | 740.14 | 9 / 21 | 34% | 30.80 | 170 / 504 |
| kidney | 56% | 688.06 | 50 / 89 | 19% | 15.33 | 171 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 206.19 | 33 / 45 |
| uterus | 35% | 183.74 | 59 / 170 | 37% | 67.86 | 172 / 459 |
| intestine | 40% | 1021.06 | 391 / 966 | 28% | 28.08 | 146 / 527 |
| adipose | 66% | 742.34 | 799 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 65% | 396.87 | 156 / 241 | 0% | 0 | 0 / 0 |
| stomach | 33% | 180.95 | 117 / 359 | 29% | 25.13 | 83 / 286 |
| blood vessel | 61% | 1206.53 | 811 / 1335 | 0% | 0 | 0 / 0 |
| heart | 34% | 438.26 | 292 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 17% | 52.55 | 45 / 258 | 13% | 6.47 | 30 / 230 |
| brain | 14% | 46.65 | 372 / 2642 | 7% | 2.67 | 50 / 705 |
| ovary | 12% | 45.48 | 22 / 180 | 6% | 2.27 | 27 / 430 |
| eye | 0% | 0 | 0 / 0 | 9% | 7.17 | 7 / 80 |
| peripheral blood | 1% | 5.89 | 12 / 929 | 0% | 0 | 0 / 0 |
| muscle | 1% | 1.71 | 5 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002407 | Biological process | dendritic cell chemotaxis |
| GO_0043507 | Biological process | positive regulation of JUN kinase activity |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_1901224 | Biological process | positive regulation of non-canonical NF-kappaB signal transduction |
| GO_0001771 | Biological process | immunological synapse formation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0050921 | Biological process | positive regulation of chemotaxis |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0031295 | Biological process | T cell costimulation |
| GO_0009615 | Biological process | response to virus |
| GO_0032735 | Biological process | positive regulation of interleukin-12 production |
| GO_2000147 | Biological process | positive regulation of cell motility |
| GO_0097029 | Biological process | mature conventional dendritic cell differentiation |
| GO_0045807 | Biological process | positive regulation of endocytosis |
| GO_0002606 | Biological process | positive regulation of dendritic cell antigen processing and presentation |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0051209 | Biological process | release of sequestered calcium ion into cytosol |
| GO_0002408 | Biological process | myeloid dendritic cell chemotaxis |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_2000549 | Biological process | positive regulation of dendritic cell dendrite assembly |
| GO_0048260 | Biological process | positive regulation of receptor-mediated endocytosis |
| GO_0032731 | Biological process | positive regulation of interleukin-1 beta production |
| GO_0006955 | Biological process | immune response |
| GO_0098586 | Biological process | cellular response to virus |
| GO_0060491 | Biological process | regulation of cell projection assembly |
| GO_0001768 | Biological process | establishment of T cell polarity |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0034695 | Biological process | response to prostaglandin E |
| GO_0071731 | Biological process | response to nitric oxide |
| GO_0090023 | Biological process | positive regulation of neutrophil chemotaxis |
| GO_0007154 | Biological process | cell communication |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| GO_0045627 | Biological process | positive regulation of T-helper 1 cell differentiation |
| GO_0010560 | Biological process | positive regulation of glycoprotein biosynthetic process |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0048469 | Biological process | cell maturation |
| GO_2000669 | Biological process | negative regulation of dendritic cell apoptotic process |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0008009 | Molecular function | chemokine activity |
| GO_0048020 | Molecular function | CCR chemokine receptor binding |
| GO_0031735 | Molecular function | CCR10 chemokine receptor binding |
| GO_0042379 | Molecular function | chemokine receptor binding |
| GO_0031732 | Molecular function | CCR7 chemokine receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CCL19 |
| Protein name | C-C motif chemokine C-C motif chemokine 19 (Beta-chemokine exodus-3) (CK beta-11) (Epstein-Barr virus-induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP-3-beta) (Small-inducible cytokine A19) |
| Synonyms | SCYA19 MIP3B hCG_20476 ELC |
| Description | FUNCTION: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. . |
| Accessions | ENST00000311925.7 Q99731 Q5VZ75 ENST00000378800.3 Q6IBD6 |
