RIPK2 | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	14 studies	23% ± 8%	Explore
monocyte	14 studies	24% ± 8%	Explore
classical monocyte	14 studies	21% ± 7%	Explore
conventional dendritic cell	13 studies	24% ± 9%	Explore
non-classical monocyte	12 studies	29% ± 11%	Explore
dendritic cell	11 studies	27% ± 14%	Explore
myeloid cell	5 studies	24% ± 7%	Explore
mast cell	3 studies	20% ± 2%	Explore
mononuclear phagocyte	3 studies	25% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	16% ± 0%	Explore
natural killer cell	3 studies	18% ± 2%	Explore
epithelial cell	3 studies	37% ± 29%	Explore
GABAergic neuron	3 studies	19% ± 2%	Explore
glutamatergic neuron	3 studies	26% ± 4%	Explore
leukocyte	3 studies	23% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	20% ± 2%	Explore
astrocyte	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	3 studies	18% ± 4%	Explore
brain	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	678.92	1445 / 1445	100%	28.54	183 / 183
lung	100%	1507.74	578 / 578	100%	29.69	1154 / 1155
breast	100%	915.76	459 / 459	100%	39.23	1116 / 1118
prostate	100%	876.47	245 / 245	100%	36.27	501 / 502
stomach	100%	586.19	359 / 359	100%	32.66	285 / 286
ovary	100%	485.38	180 / 180	100%	31.26	428 / 430
bladder	100%	734.81	21 / 21	99%	35.18	501 / 504
intestine	100%	747.81	965 / 966	99%	30.70	524 / 527
uterus	100%	745.99	170 / 170	99%	27.49	455 / 459
skin	100%	1329.10	1808 / 1809	99%	25.44	465 / 472
thymus	100%	589.20	651 / 653	96%	15.72	583 / 605
kidney	100%	560.81	89 / 89	94%	18.69	850 / 901
pancreas	98%	522.13	322 / 328	96%	28.23	171 / 178
brain	91%	422.13	2404 / 2642	100%	28.90	702 / 705
liver	95%	407.27	215 / 226	84%	16.63	340 / 406
adrenal gland	99%	401.81	256 / 258	39%	3.98	90 / 230
adipose	100%	1035.83	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	42.53	29 / 29
spleen	100%	817.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	21.96	45 / 45
ureter	0%	0	0 / 0	100%	34.56	1 / 1
blood vessel	100%	909.79	1334 / 1335	0%	0	0 / 0
peripheral blood	99%	1323.40	917 / 929	0%	0	0 / 0
heart	97%	557.92	836 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	17.10	76 / 80
muscle	23%	47.46	182 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007254	Biological process	JNK cascade
GO_0051260	Biological process	protein homooligomerization
GO_0032722	Biological process	positive regulation of chemokine production
GO_0032728	Biological process	positive regulation of interferon-beta production
GO_0070427	Biological process	nucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0006954	Biological process	inflammatory response
GO_1902523	Biological process	positive regulation of protein K63-linked ubiquitination
GO_0035739	Biological process	CD4-positive, alpha-beta T cell proliferation
GO_0043330	Biological process	response to exogenous dsRNA
GO_0001961	Biological process	positive regulation of cytokine-mediated signaling pathway
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0033092	Biological process	positive regulation of immature T cell proliferation in thymus
GO_2000563	Biological process	positive regulation of CD4-positive, alpha-beta T cell proliferation
GO_0034142	Biological process	toll-like receptor 4 signaling pathway
GO_0070671	Biological process	response to interleukin-12
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0033080	Biological process	immature T cell proliferation in thymus
GO_0045087	Biological process	innate immune response
GO_0007165	Biological process	signal transduction
GO_0070673	Biological process	response to interleukin-18
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0051403	Biological process	stress-activated MAPK cascade
GO_0070371	Biological process	ERK1 and ERK2 cascade
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0071223	Biological process	cellular response to lipoteichoic acid
GO_0070431	Biological process	nucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_0002827	Biological process	positive regulation of T-helper 1 type immune response
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0098792	Biological process	xenophagy
GO_0032874	Biological process	positive regulation of stress-activated MAPK cascade
GO_0007249	Biological process	canonical NF-kappaB signal transduction
GO_0032092	Biological process	positive regulation of protein binding
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0071224	Biological process	cellular response to peptidoglycan
GO_0032727	Biological process	positive regulation of interferon-alpha production
GO_0032743	Biological process	positive regulation of interleukin-2 production
GO_0032731	Biological process	positive regulation of interleukin-1 beta production
GO_0060907	Biological process	positive regulation of macrophage cytokine production
GO_0034134	Biological process	toll-like receptor 2 signaling pathway
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0031663	Biological process	lipopolysaccharide-mediated signaling pathway
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_0070555	Biological process	response to interleukin-1
GO_0097202	Biological process	activation of cysteine-type endopeptidase activity
GO_1904417	Biological process	positive regulation of xenophagy
GO_0002250	Biological process	adaptive immune response
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0042742	Biological process	defense response to bacterium
GO_0006915	Biological process	apoptotic process
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0045627	Biological process	positive regulation of T-helper 1 cell differentiation
GO_0071225	Biological process	cellular response to muramyl dipeptide
GO_0010800	Biological process	positive regulation of peptidyl-threonine phosphorylation
GO_0005856	Cellular component	cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0005829	Cellular component	cytosol
GO_0031982	Cellular component	vesicle
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding
GO_0089720	Molecular function	caspase binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0005102	Molecular function	signaling receptor binding
GO_0004715	Molecular function	non-membrane spanning protein tyrosine kinase activity
GO_0030274	Molecular function	LIM domain binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0035591	Molecular function	signaling adaptor activity
GO_0004706	Molecular function	JUN kinase kinase kinase activity
GO_0005515	Molecular function	protein binding
GO_0050700	Molecular function	CARD domain binding
GO_0042803	Molecular function	protein homodimerization activity

IV. Literature review

[source]

Gene name	RIPK2
Protein name	Receptor-interacting serine-threonine kinase 2 isoform b Receptor interacting serine/threonine kinase 2 (Receptor-interacting serine-threonine kinase 2 isoform 2) Receptor-interacting serine-threonine kinase 2 isoform 1 Receptor interacting serine/threonine kinase 2 Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Synonyms	UNQ277/PRO314/PRO34092 CARDIAK RICK RIP2
Description	FUNCTION: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses . Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments . Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors . 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process . 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB . In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis . The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways . Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 . Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation . Plays a role in the inactivation of RHOA in response to NGFR signaling . .
Accessions	A0A0S2Z4Z8 O43353 Q6Q322 ENST00000517696.1 E5RGK6 ENST00000522965.1 E7ERW9 ENST00000220751.5 [O43353-1]

RIPK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review