TXNIP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	45 studies	53% ± 20%	Explore
B cell	44 studies	66% ± 25%	Explore
natural killer cell	42 studies	69% ± 23%	Explore
endothelial cell	41 studies	51% ± 23%	Explore
fibroblast	39 studies	45% ± 18%	Explore
T cell	36 studies	51% ± 21%	Explore
CD8-positive, alpha-beta T cell	36 studies	64% ± 21%	Explore
pericyte	35 studies	56% ± 22%	Explore
CD4-positive, alpha-beta T cell	32 studies	71% ± 20%	Explore
smooth muscle cell	30 studies	48% ± 20%	Explore
endothelial cell of lymphatic vessel	25 studies	55% ± 21%	Explore
conventional dendritic cell	25 studies	55% ± 22%	Explore
dendritic cell	24 studies	55% ± 19%	Explore
monocyte	24 studies	58% ± 19%	Explore
classical monocyte	24 studies	63% ± 17%	Explore
non-classical monocyte	24 studies	75% ± 18%	Explore
mast cell	23 studies	45% ± 18%	Explore
mature NK T cell	23 studies	71% ± 21%	Explore
regulatory T cell	23 studies	69% ± 22%	Explore
plasma cell	21 studies	46% ± 18%	Explore
memory B cell	20 studies	75% ± 20%	Explore
naive B cell	19 studies	76% ± 19%	Explore
gamma-delta T cell	18 studies	72% ± 19%	Explore
epithelial cell	17 studies	45% ± 23%	Explore
capillary endothelial cell	17 studies	59% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	74% ± 22%	Explore
mucosal invariant T cell	16 studies	77% ± 20%	Explore
basal cell	16 studies	53% ± 22%	Explore
ciliated cell	16 studies	47% ± 16%	Explore
connective tissue cell	16 studies	50% ± 22%	Explore
endothelial cell of artery	16 studies	60% ± 18%	Explore
vein endothelial cell	16 studies	55% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	80% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	81% ± 16%	Explore
myeloid cell	15 studies	43% ± 21%	Explore
myofibroblast cell	14 studies	48% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	73% ± 19%	Explore
neutrophil	13 studies	58% ± 18%	Explore
endothelial cell of vascular tree	13 studies	45% ± 17%	Explore
innate lymphoid cell	12 studies	70% ± 22%	Explore
microglial cell	12 studies	35% ± 17%	Explore
mesothelial cell	12 studies	43% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	83% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	65% ± 18%	Explore
secretory cell	11 studies	48% ± 15%	Explore
adipocyte	11 studies	53% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	68% ± 17%	Explore
plasmablast	10 studies	51% ± 27%	Explore
plasmacytoid dendritic cell	10 studies	48% ± 21%	Explore
astrocyte	10 studies	26% ± 13%	Explore
type I pneumocyte	9 studies	32% ± 14%	Explore
type II pneumocyte	9 studies	50% ± 17%	Explore
club cell	9 studies	38% ± 22%	Explore
leukocyte	9 studies	49% ± 15%	Explore
alveolar macrophage	8 studies	82% ± 11%	Explore
respiratory goblet cell	8 studies	45% ± 20%	Explore
kidney loop of Henle epithelial cell	8 studies	48% ± 21%	Explore
renal alpha-intercalated cell	8 studies	69% ± 24%	Explore
abnormal cell	8 studies	36% ± 25%	Explore
oligodendrocyte	8 studies	24% ± 5%	Explore
IgG plasma cell	8 studies	47% ± 7%	Explore
hematopoietic stem cell	8 studies	59% ± 19%	Explore
kidney distal convoluted tubule epithelial cell	7 studies	51% ± 29%	Explore
IgA plasma cell	7 studies	42% ± 8%	Explore
T follicular helper cell	7 studies	69% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	72% ± 19%	Explore
hematopoietic precursor cell	6 studies	38% ± 24%	Explore
ionocyte	6 studies	47% ± 20%	Explore
platelet	6 studies	54% ± 24%	Explore
erythrocyte	6 studies	61% ± 23%	Explore
progenitor cell	6 studies	37% ± 9%	Explore
goblet cell	6 studies	37% ± 12%	Explore
lymphocyte	6 studies	52% ± 17%	Explore
immature B cell	6 studies	68% ± 25%	Explore
cardiac muscle cell	6 studies	50% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	79% ± 20%	Explore
oligodendrocyte precursor cell	6 studies	25% ± 6%	Explore
CD4-positive helper T cell	5 studies	64% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	77% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	54% ± 24%	Explore
enterocyte	5 studies	26% ± 9%	Explore
precursor B cell	5 studies	55% ± 9%	Explore
pro-B cell	5 studies	44% ± 15%	Explore
adventitial cell	5 studies	52% ± 12%	Explore
deuterosomal cell	4 studies	24% ± 8%	Explore
squamous epithelial cell	4 studies	45% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	51% ± 15%	Explore
mononuclear phagocyte	4 studies	47% ± 9%	Explore
glomerular endothelial cell	4 studies	88% ± 4%	Explore
kidney connecting tubule epithelial cell	4 studies	71% ± 24%	Explore
podocyte	4 studies	47% ± 23%	Explore
parietal epithelial cell	4 studies	52% ± 26%	Explore
renal principal cell	4 studies	61% ± 25%	Explore
brush cell	4 studies	49% ± 27%	Explore
glial cell	4 studies	40% ± 13%	Explore
T-helper 17 cell	4 studies	64% ± 17%	Explore
inflammatory macrophage	4 studies	53% ± 11%	Explore
hepatocyte	4 studies	31% ± 16%	Explore
granulocyte	4 studies	51% ± 24%	Explore
luminal cell of prostate epithelium	4 studies	35% ± 9%	Explore
intermediate monocyte	4 studies	55% ± 29%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	54% ± 10%	Explore
duct epithelial cell	3 studies	46% ± 8%	Explore
hillock cell	3 studies	29% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	47% ± 19%	Explore
epithelial cell of proximal tubule	3 studies	42% ± 13%	Explore
intestinal crypt stem cell	3 studies	34% ± 10%	Explore
transit amplifying cell	3 studies	24% ± 3%	Explore
erythroblast	3 studies	50% ± 26%	Explore
endocardial cell	3 studies	49% ± 8%	Explore
tissue-resident macrophage	3 studies	50% ± 4%	Explore
germinal center B cell	3 studies	25% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	34% ± 9%	Explore
myoepithelial cell	3 studies	44% ± 21%	Explore
endothelial cell of sinusoid	3 studies	34% ± 11%	Explore
muscle cell	3 studies	32% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	79% ± 7%	Explore
mucus secreting cell	3 studies	27% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	65% ± 11%	Explore
keratinocyte	3 studies	27% ± 2%	Explore
T-helper 1 cell	3 studies	67% ± 33%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	98% ± 1%	Explore
double negative thymocyte	3 studies	84% ± 17%	Explore
mural cell	3 studies	56% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	51% ± 20%	Explore
peripheral blood	17 studies	77% ± 19%	Explore
intestine	10 studies	43% ± 22%	Explore
kidney	10 studies	41% ± 20%	Explore
heart	7 studies	38% ± 11%	Explore
brain	6 studies	28% ± 12%	Explore
liver	5 studies	32% ± 7%	Explore
bone marrow	5 studies	51% ± 24%	Explore
adipose	5 studies	46% ± 25%	Explore
breast	5 studies	39% ± 11%	Explore
uterus	4 studies	65% ± 13%	Explore
prostate	4 studies	25% ± 8%	Explore
esophagus	3 studies	25% ± 7%	Explore
pancreas	3 studies	20% ± 5%	Explore
lymph node	3 studies	67% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	204317.70	459 / 459	97%	583.16	1089 / 1118
kidney	98%	61147.56	87 / 89	99%	872.01	889 / 901
thymus	96%	83997.44	630 / 653	99%	759.69	600 / 605
lung	99%	117780.48	575 / 578	94%	513.00	1080 / 1155
bladder	100%	103274.29	21 / 21	92%	411.90	462 / 504
intestine	99%	124957.55	957 / 966	92%	429.05	485 / 527
prostate	92%	51607.82	226 / 245	99%	533.01	495 / 502
stomach	95%	86682.09	342 / 359	93%	366.22	265 / 286
uterus	100%	114342.69	170 / 170	88%	380.36	403 / 459
esophagus	92%	122130.63	1326 / 1445	84%	327.79	153 / 183
ovary	82%	48635.90	148 / 180	91%	330.34	391 / 430
adrenal gland	85%	63705.98	220 / 258	85%	303.25	196 / 230
pancreas	73%	30174.60	241 / 328	97%	917.57	172 / 178
skin	75%	104406.47	1354 / 1809	83%	291.63	393 / 472
brain	6%	1712.43	152 / 2642	96%	357.99	680 / 705
spleen	100%	124050.95	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	158.75	1 / 1
adipose	100%	184360.31	1203 / 1204	0%	0	0 / 0
muscle	96%	117477.00	772 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	335.24	41 / 45
heart	88%	52791.26	757 / 861	0%	0	0 / 0
blood vessel	85%	54050.37	1129 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	303.28	24 / 29
peripheral blood	79%	92265.14	735 / 929	0%	0	0 / 0
liver	8%	2352.54	18 / 226	62%	192.21	251 / 406
eye	0%	0	0 / 0	65%	135.34	52 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071228	Biological process	cellular response to tumor cell
GO_0042542	Biological process	response to hydrogen peroxide
GO_0030216	Biological process	keratinocyte differentiation
GO_0032355	Biological process	response to estradiol
GO_0006954	Biological process	inflammatory response
GO_0009749	Biological process	response to glucose
GO_0051782	Biological process	negative regulation of cell division
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0048008	Biological process	platelet-derived growth factor receptor signaling pathway
GO_0006606	Biological process	protein import into nucleus
GO_0140052	Biological process	cellular response to oxidised low-density lipoprotein particle stimulus
GO_0015031	Biological process	protein transport
GO_0009612	Biological process	response to mechanical stimulus
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0032570	Biological process	response to progesterone
GO_0006979	Biological process	response to oxidative stress
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0051592	Biological process	response to calcium ion
GO_0042127	Biological process	regulation of cell population proliferation
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004857	Molecular function	enzyme inhibitor activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TXNIP
Protein name	Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) Alternative protein TXNIP Thioredoxin-interacting protein
Synonyms	VDUP1 RP11-315I20.4-002
Description	FUNCTION: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). .
Accessions	L8E7V6 Q9H3M7 B1ALI9 ENST00000425134.2 [Q9H3M7-2] ENST00000582401.6 [Q9H3M7-1]

TXNIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review