NCR3 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	30 studies	32% ± 10%	Explore
mucosal invariant T cell	16 studies	42% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	40% ± 10%	Explore
mature NK T cell	11 studies	38% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	32% ± 9%	Explore
gamma-delta T cell	9 studies	26% ± 8%	Explore
memory B cell	8 studies	20% ± 2%	Explore
B cell	8 studies	18% ± 3%	Explore
CD8-positive, alpha-beta T cell	6 studies	25% ± 7%	Explore
innate lymphoid cell	4 studies	33% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	32% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	34% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	23% ± 5%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NCR3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	97%	85.21	563 / 578	64%	2.07	735 / 1155
liver	82%	25.45	185 / 226	39%	1.29	159 / 406
kidney	54%	16.16	48 / 89	61%	1.59	552 / 901
spleen	100%	707.61	241 / 241	0%	0	0 / 0
peripheral blood	100%	1062.75	928 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	13.88	28 / 29
breast	54%	12.61	250 / 459	41%	1.48	459 / 1118
thymus	46%	16.72	303 / 653	40%	2.24	245 / 605
intestine	45%	64.45	433 / 966	38%	1.06	201 / 527
uterus	32%	5.56	55 / 170	48%	1.51	222 / 459
tonsil	0%	0	0 / 0	78%	3.76	35 / 45
skin	27%	5.15	497 / 1809	49%	2.53	232 / 472
bladder	43%	19.38	9 / 21	30%	0.78	153 / 504
stomach	28%	6.64	101 / 359	40%	0.98	115 / 286
adipose	68%	21.77	818 / 1204	0%	0	0 / 0
prostate	42%	10.86	102 / 245	23%	0.52	117 / 502
pancreas	3%	0.44	10 / 328	50%	2.00	89 / 178
ovary	14%	2.87	25 / 180	31%	0.67	132 / 430
esophagus	22%	5.31	322 / 1445	19%	0.49	35 / 183
brain	19%	2.94	513 / 2642	6%	0.13	42 / 705
heart	25%	4.51	217 / 861	0%	0	0 / 0
blood vessel	22%	6.57	288 / 1335	0%	0	0 / 0
adrenal gland	12%	1.77	31 / 258	7%	0.15	17 / 230
muscle	6%	0.89	52 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.20	4 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006955	Biological process	immune response
GO_0030101	Biological process	natural killer cell activation
GO_0006954	Biological process	inflammatory response
GO_0008037	Biological process	cell recognition
GO_0045954	Biological process	positive regulation of natural killer cell mediated cytotoxicity
GO_0002429	Biological process	immune response-activating cell surface receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0005515	Molecular function	protein binding
GO_0042802	Molecular function	identical protein binding

IV. Literature review

[source]

Gene name	NCR3
Protein name	Natural cytotoxicity triggering receptor 3 (Natural killer cell p30-related protein) Natural cytotoxicity triggering receptor 3 Natural cytotoxicity triggering receptor 3 (Activating natural killer receptor p30) (Natural killer cell p30-related protein) (NK-p30) (NKp30) (CD antigen CD337)
Synonyms	hCG_43721 1C7 LY117
Description	FUNCTION: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. .
Accessions	Q05D23 ENST00000496945.1 ENST00000376073.8 [O14931-3] ENST00000418936.6 [O14931-2] ENST00000419728.6 [O14931-5] ENST00000435674.6 [O14931-1] ENST00000376071.4 [O14931-5] ENST00000457547.5 [O14931-2] ENST00000437517.6 [O14931-1] ENST00000465928.2 ENST00000447248.6 [O14931-1] ENST00000383476.6 [O14931-2] ENST00000488139.1 ENST00000415123.6 [O14931-1] ENST00000441372.5 [O14931-2] ENST00000452296.6 [O14931-2] ENST00000412603.5 [O14931-2] ENST00000438663.6 [O14931-5] ENST00000455825.6 [O14931-3] ENST00000376072.7 [O14931-2] ENST00000493663.1 ENST00000340027.10 [O14931-1] ENST00000446756.6 [O14931-3] ENST00000383477.8 [O14931-1] ENST00000420556.6 [O14931-1] ENST00000433654.6 [O14931-3] ENST00000383478.8 [O14931-3] ENST00000480313.1 A0A0G2JKT7 ENST00000420485.6 [O14931-5] ENST00000419086.6 [O14931-5] ENST00000439584.6 [O14931-3] ENST00000470666.1 O14931 ENST00000430599.6 [O14931-1] ENST00000436253.6 [O14931-3] ENST00000400241.7 [O14931-5] ENST00000455448.6 [O14931-5] ENST00000432392.6 [O14931-3] ENST00000453657.6 [O14931-5] ENST00000436623.5 [O14931-2] ENST00000463064.1

NCR3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review