Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 15 studies | 36% ± 15% | |
| myeloid cell | 6 studies | 25% ± 8% | |
| alveolar macrophage | 4 studies | 27% ± 8% | |
| monocyte | 3 studies | 24% ± 6% | |
| tissue-resident macrophage | 3 studies | 29% ± 9% |
Insufficient scRNA-seq data for expression of SIGLEC1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 97% | 5119.22 | 563 / 578 | 87% | 11.15 | 1008 / 1155 |
| breast | 86% | 2485.70 | 395 / 459 | 92% | 10.27 | 1023 / 1118 |
| bladder | 100% | 2096.10 | 21 / 21 | 60% | 6.37 | 301 / 504 |
| intestine | 99% | 2797.89 | 952 / 966 | 53% | 3.77 | 280 / 527 |
| esophagus | 75% | 2093.76 | 1090 / 1445 | 72% | 5.73 | 132 / 183 |
| adrenal gland | 95% | 3761.08 | 246 / 258 | 47% | 3.54 | 109 / 230 |
| thymus | 75% | 1068.28 | 491 / 653 | 67% | 3.83 | 403 / 605 |
| ovary | 50% | 702.78 | 90 / 180 | 86% | 10.74 | 370 / 430 |
| stomach | 68% | 1234.05 | 244 / 359 | 67% | 5.97 | 192 / 286 |
| liver | 68% | 1157.96 | 154 / 226 | 60% | 3.51 | 242 / 406 |
| kidney | 48% | 872.97 | 43 / 89 | 76% | 8.44 | 689 / 901 |
| uterus | 49% | 602.33 | 83 / 170 | 73% | 5.90 | 336 / 459 |
| skin | 36% | 471.85 | 649 / 1809 | 85% | 11.26 | 401 / 472 |
| spleen | 98% | 5106.66 | 237 / 241 | 0% | 0 | 0 / 0 |
| adipose | 98% | 6126.31 | 1181 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 16% | 122.77 | 52 / 328 | 81% | 8.02 | 145 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 21.59 | 25 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 6.85 | 37 / 45 |
| heart | 74% | 1148.25 | 635 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 69% | 1738.88 | 923 / 1335 | 0% | 0 | 0 / 0 |
| brain | 5% | 62.33 | 144 / 2642 | 62% | 6.68 | 440 / 705 |
| prostate | 39% | 417.15 | 95 / 245 | 29% | 1.12 | 145 / 502 |
| eye | 0% | 0 | 0 / 0 | 64% | 4.06 | 51 / 80 |
| muscle | 54% | 513.89 | 430 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 20% | 363.09 | 187 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032480 | Biological process | negative regulation of type I interferon production |
| GO_0075512 | Biological process | clathrin-dependent endocytosis of virus by host cell |
| GO_0006954 | Biological process | inflammatory response |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005770 | Cellular component | late endosome |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005769 | Cellular component | early endosome |
| GO_0030246 | Molecular function | carbohydrate binding |
| GO_0046790 | Molecular function | virion binding |
| Gene name | SIGLEC1 |
| Protein name | SIGLEC1 protein Sialic acid binding Ig like lectin 1 Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169) |
| Synonyms | SN |
| Description | FUNCTION: Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response . Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 . Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid . Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination . .; FUNCTION: (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane. . |
| Accessions | H7C0M6 ENST00000344754.6 [Q9BZZ2-1] ENST00000419548.4 Q9BZZ2 A5D8Z7 ENST00000707083.1 [Q9BZZ2-3] |
