AOC3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AOC3 at tissue level.

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0007155Biological processcell adhesion
GO_0046677Biological processresponse to antibiotic
GO_1902283Biological processnegative regulation of primary amine oxidase activity
GO_0009308Biological processamine metabolic process
GO_0005902Cellular componentmicrovillus
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0005794Cellular componentGolgi apparatus
GO_0009986Cellular componentcell surface
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0052595Molecular functionaliphatic amine oxidase activity
GO_0008131Molecular functionprimary amine oxidase activity
GO_0042802Molecular functionidentical protein binding
GO_0048038Molecular functionquinone binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005507Molecular functioncopper ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAOC3
Protein nameAmine oxidase (EC 1.4.3.-)
Amine oxidase [copper-containing] 3 (EC 1.4.3.21) (Amine oxidase copper-containing 3) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1)
SynonymsVAP1
DescriptionFUNCTION: Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia . Has a preference for the primary monoamines methylamine and benzylamine . Could also act on 2-phenylethylamine but much less efficiently . At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion . .; FUNCTION: [Isoform 2]: Has no semicarbazide-sensitive amine oxidase (SSAO) activity. .

AccessionsK7EIK5
Q16853
K7EQZ5
ENST00000587330.1
ENST00000613571.1 [Q16853-2]
ENST00000592999.5
ENST00000617500.4 [Q16853-3]
ENST00000308423.7 [Q16853-1]
ENST00000588033.1
ENST00000591562.1 [Q16853-3]
K7EL47