NFKBIB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0007165Biological processsignal transduction
GO_0006351Biological processDNA-templated transcription
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006954Biological processinflammatory response
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFKBIB
Protein nameNFKB inhibitor beta
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
SynonymsTRIP9
IKBB
DescriptionFUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

AccessionsENST00000572515.5 [Q15653-2]
Q15653
ENST00000575359.5
I3L1A4
H0YFH0
G5E9C2
ENST00000634647.1 [Q15653-2]
I3L4X3
ENST00000509705.3
ENST00000313582.6 [Q15653-1]
ENST00000576510.5
ENST00000635517.2 [Q15653-1]
ENST00000392079.7