Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| natural killer cell | 12 studies | 25% ± 6% | |
| CD16-negative, CD56-bright natural killer cell, human | 9 studies | 22% ± 5% | |
| CD16-positive, CD56-dim natural killer cell, human | 8 studies | 26% ± 6% | |
| gamma-delta T cell | 6 studies | 21% ± 6% | |
| CD8-positive, alpha-beta T cell | 5 studies | 22% ± 3% | |
| mature NK T cell | 4 studies | 19% ± 1% | |
| non-classical monocyte | 4 studies | 21% ± 5% | |
| CD8-positive, alpha-beta memory T cell | 4 studies | 21% ± 5% | |
| B cell | 3 studies | 19% ± 4% | |
| classical monocyte | 3 studies | 21% ± 3% | |
| effector memory CD8-positive, alpha-beta T cell | 3 studies | 22% ± 6% | |
| memory B cell | 3 studies | 19% ± 2% | |
| mucosal invariant T cell | 3 studies | 22% ± 1% | |
| epithelial cell | 3 studies | 35% ± 15% | |
| dendritic cell | 3 studies | 25% ± 7% | |
| mast cell | 3 studies | 18% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| peripheral blood | 4 studies | 19% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1693.96 | 1445 / 1445 | 100% | 42.09 | 183 / 183 |
| liver | 100% | 1664.47 | 226 / 226 | 100% | 41.96 | 406 / 406 |
| ovary | 100% | 975.01 | 180 / 180 | 100% | 35.98 | 430 / 430 |
| skin | 100% | 1623.62 | 1809 / 1809 | 100% | 41.84 | 472 / 472 |
| thymus | 100% | 1496.17 | 653 / 653 | 100% | 38.06 | 605 / 605 |
| uterus | 100% | 1117.67 | 170 / 170 | 100% | 57.69 | 459 / 459 |
| brain | 100% | 1536.64 | 2640 / 2642 | 100% | 43.23 | 705 / 705 |
| intestine | 100% | 1490.63 | 966 / 966 | 100% | 50.26 | 525 / 527 |
| pancreas | 99% | 701.64 | 326 / 328 | 100% | 50.23 | 178 / 178 |
| kidney | 100% | 1534.96 | 89 / 89 | 99% | 30.00 | 895 / 901 |
| prostate | 100% | 1380.03 | 245 / 245 | 99% | 32.37 | 498 / 502 |
| adrenal gland | 100% | 1508.64 | 258 / 258 | 99% | 28.21 | 228 / 230 |
| stomach | 100% | 1324.58 | 359 / 359 | 99% | 48.79 | 283 / 286 |
| lung | 100% | 1710.09 | 578 / 578 | 99% | 43.06 | 1141 / 1155 |
| bladder | 100% | 1566.48 | 21 / 21 | 98% | 54.93 | 496 / 504 |
| breast | 100% | 1342.95 | 459 / 459 | 98% | 31.38 | 1093 / 1118 |
| adipose | 100% | 1391.44 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 37.75 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 93.51 | 29 / 29 |
| muscle | 100% | 1811.93 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1678.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 53.16 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 42.83 | 1 / 1 |
| blood vessel | 100% | 1653.15 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 1664.05 | 920 / 929 | 0% | 0 | 0 / 0 |
| heart | 99% | 1199.51 | 851 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0007165 | Biological process | signal transduction |
| GO_0006351 | Biological process | DNA-templated transcription |
| GO_0043122 | Biological process | regulation of canonical NF-kappaB signal transduction |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0006954 | Biological process | inflammatory response |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NFKBIB |
| Protein name | NFKB inhibitor beta NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9) |
| Synonyms | TRIP9 IKBB |
| Description | FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Accessions | ENST00000572515.5 [Q15653-2] Q15653 ENST00000575359.5 I3L1A4 H0YFH0 G5E9C2 ENST00000634647.1 [Q15653-2] I3L4X3 ENST00000509705.3 ENST00000313582.6 [Q15653-1] ENST00000576510.5 ENST00000635517.2 [Q15653-1] ENST00000392079.7 |