IRF5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IRF5 at tissue level.

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0002376Biological processimmune system process
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032495Biological processresponse to muramyl dipeptide
GO_0051607Biological processdefense response to virus
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0032481Biological processpositive regulation of type I interferon production
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0032494Biological processresponse to peptidoglycan
GO_0098586Biological processcellular response to virus
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIRF5
Protein nameInterferon regulatory factor 5 transcript variant 13
Interferon regulatory factor 5 transcript variant 17
Interferon regulatory factor 5 transcript variant 15
Interferon regulatory factor 5 variant 9
Interferon regulatory factor 5
Interferon regulatory factor 5 variant 7
Interferon regulatory factor 5 (IRF-5)
Interferon regulatory factor 5 transcript variant 14
Interferon regulatory factor 5 transcript variant 16
Synonyms
DescriptionFUNCTION: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 . Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection . .

AccessionsENST00000473745.5 [Q13568-1]
A0A0G2USB5
A0A0G2UM11
A0A0G2UUJ1
F8WDH6
ENST00000357234.10 [Q13568-2]
ENST00000700149.1
C9JB67
Q13568
ENST00000473787.5
I6ZU14
C9JYP7
ENST00000402030.6 [Q13568-1]
I6YQ35
C9J7M2
ENST00000489702.6 [Q13568-2]
Q64GB0
I6Z0J2
ENST00000700150.1
I6ZY36
Q64GA8
ENST00000465603.5 [Q13568-6]
I6ZKX6
ENST00000477535.5 [Q13568-5]
ENST00000464557.5
ENST00000479582.5
ENST00000467002.1
ENST00000652525.1