CHST4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CHST4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHST4 at tissue level.

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0005975Biological processcarbohydrate metabolic process
GO_0016266Biological processO-glycan processing
GO_0006044Biological processN-acetylglucosamine metabolic process
GO_0006954Biological processinflammatory response
GO_0007155Biological processcell adhesion
GO_0006790Biological processsulfur compound metabolic process
GO_0007267Biological processcell-cell signaling
GO_0006477Biological processprotein sulfation
GO_1903238Biological processpositive regulation of leukocyte tethering or rolling
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0008146Molecular functionsulfotransferase activity
GO_0001517Molecular functionN-acetylglucosamine 6-O-sulfotransferase activity

IV. Literature review

[source]
Gene nameCHST4
Protein nameCarbohydrate sulfotransferase 4 (EC 2.8.2.-) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3) (GST-3) (High endothelial cells N-acetylglucosamine 6-O-sulfotransferase) (HEC-GlcNAc6ST) (L-selectin ligand sulfotransferase) (LSST) (N-acetylglucosamine 6-O-sulfotransferase 2) (GlcNAc6ST-2) (Gn6st-2)
Synonyms
DescriptionFUNCTION: Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans. Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance . Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs) . The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing. Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (By similarity). Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis . .

AccessionsENST00000539698.4
ENST00000338482.5
Q8NCG5