Insufficient scRNA-seq data for expression of TNFSF4 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 99% | 238.23 | 242 / 245 | 96% | 3.59 | 482 / 502 |
| lung | 100% | 221.44 | 577 / 578 | 92% | 4.41 | 1066 / 1155 |
| brain | 99% | 164.84 | 2606 / 2642 | 93% | 2.56 | 658 / 705 |
| ovary | 100% | 151.06 | 180 / 180 | 88% | 5.07 | 377 / 430 |
| adrenal gland | 99% | 192.27 | 255 / 258 | 87% | 5.69 | 201 / 230 |
| breast | 88% | 79.75 | 406 / 459 | 96% | 7.64 | 1073 / 1118 |
| intestine | 97% | 145.05 | 940 / 966 | 81% | 4.22 | 426 / 527 |
| kidney | 93% | 88.67 | 83 / 89 | 81% | 2.98 | 731 / 901 |
| pancreas | 80% | 55.96 | 264 / 328 | 93% | 6.65 | 165 / 178 |
| stomach | 87% | 110.21 | 311 / 359 | 86% | 4.22 | 246 / 286 |
| uterus | 98% | 144.71 | 166 / 170 | 73% | 3.46 | 335 / 459 |
| bladder | 100% | 150.14 | 21 / 21 | 70% | 3.58 | 353 / 504 |
| skin | 75% | 307.22 | 1351 / 1809 | 90% | 6.76 | 426 / 472 |
| thymus | 91% | 82.06 | 594 / 653 | 73% | 2.97 | 439 / 605 |
| esophagus | 85% | 241.79 | 1232 / 1445 | 69% | 2.46 | 127 / 183 |
| liver | 83% | 80.34 | 187 / 226 | 70% | 2.97 | 285 / 406 |
| spleen | 100% | 270.10 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 97% | 120.58 | 1299 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 97% | 128.79 | 1166 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 15.42 | 28 / 29 |
| peripheral blood | 91% | 379.13 | 841 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 4.76 | 39 / 45 |
| heart | 84% | 96.46 | 723 / 861 | 0% | 0 | 0 / 0 |
| muscle | 30% | 17.33 | 242 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 18% | 0.33 | 14 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071380 | Biological process | cellular response to prostaglandin E stimulus |
| GO_0050871 | Biological process | positive regulation of B cell activation |
| GO_0032722 | Biological process | positive regulation of chemokine production |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_1900281 | Biological process | positive regulation of CD4-positive, alpha-beta T cell costimulation |
| GO_0002726 | Biological process | positive regulation of T cell cytokine production |
| GO_0006954 | Biological process | inflammatory response |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0002215 | Biological process | defense response to nematode |
| GO_0002639 | Biological process | positive regulation of immunoglobulin production |
| GO_0032753 | Biological process | positive regulation of interleukin-4 production |
| GO_0043382 | Biological process | positive regulation of memory T cell differentiation |
| GO_0007165 | Biological process | signal transduction |
| GO_0009615 | Biological process | response to virus |
| GO_0032736 | Biological process | positive regulation of interleukin-13 production |
| GO_0032735 | Biological process | positive regulation of interleukin-12 production |
| GO_0035713 | Biological process | response to nitrogen dioxide |
| GO_0002891 | Biological process | positive regulation of immunoglobulin mediated immune response |
| GO_0032733 | Biological process | positive regulation of interleukin-10 production |
| GO_0002526 | Biological process | acute inflammatory response |
| GO_0050727 | Biological process | regulation of inflammatory response |
| GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
| GO_0002819 | Biological process | regulation of adaptive immune response |
| GO_0006955 | Biological process | immune response |
| GO_0035709 | Biological process | memory T cell activation |
| GO_0035712 | Biological process | T-helper 2 cell activation |
| GO_2000572 | Biological process | positive regulation of interleukin-4-dependent isotype switching to IgE isotypes |
| GO_0046641 | Biological process | positive regulation of alpha-beta T cell proliferation |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0032689 | Biological process | negative regulation of type II interferon production |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0045590 | Biological process | negative regulation of regulatory T cell differentiation |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0001819 | Biological process | positive regulation of cytokine production |
| GO_0032700 | Biological process | negative regulation of interleukin-17 production |
| GO_0045626 | Biological process | negative regulation of T-helper 1 cell differentiation |
| GO_0043372 | Biological process | positive regulation of CD4-positive, alpha-beta T cell differentiation |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0002830 | Biological process | positive regulation of type 2 immune response |
| GO_0045630 | Biological process | positive regulation of T-helper 2 cell differentiation |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0032813 | Molecular function | tumor necrosis factor receptor superfamily binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005164 | Molecular function | tumor necrosis factor receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | TNFSF4 |
| Protein name | TNFSF4 protein Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252) |
| Synonyms | TXGP1 |
| Description | FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. |
| Accessions | P23510 ENST00000367718.5 [P23510-2] ENST00000281834.4 [P23510-1] Q6FGS4 |
