HAVCR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002826Biological processnegative regulation of T-helper 1 type immune response
GO_0032722Biological processpositive regulation of chemokine production
GO_0042102Biological processpositive regulation of T cell proliferation
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0006954Biological processinflammatory response
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0034154Biological processtoll-like receptor 7 signaling pathway
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0010629Biological processnegative regulation of gene expression
GO_0030886Biological processnegative regulation of myeloid dendritic cell activation
GO_0032687Biological processnegative regulation of interferon-alpha production
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0032712Biological processnegative regulation of interleukin-3 production
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_2000521Biological processnegative regulation of immunological synapse formation
GO_0002519Biological processnatural killer cell tolerance induction
GO_0032732Biological processpositive regulation of interleukin-1 production
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0043032Biological processpositive regulation of macrophage activation
GO_0071656Biological processnegative regulation of granulocyte colony-stimulating factor production
GO_0002250Biological processadaptive immune response
GO_0002859Biological processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO_0002652Biological processregulation of tolerance induction dependent upon immune response
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0032815Biological processnegative regulation of natural killer cell activation
GO_0042130Biological processnegative regulation of T cell proliferation
GO_2001189Biological processnegative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0002281Biological processmacrophage activation involved in immune response
GO_0032689Biological processnegative regulation of type II interferon production
GO_1900425Biological processnegative regulation of defense response to bacterium
GO_0032729Biological processpositive regulation of type II interferon production
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_1900426Biological processpositive regulation of defense response to bacterium
GO_0034162Biological processtoll-like receptor 9 signaling pathway
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0001772Cellular componentimmunological synapse
GO_0016592Cellular componentmediator complex
GO_0005769Cellular componentearly endosome
GO_0009986Cellular componentcell surface
GO_0070161Cellular componentanchoring junction
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHAVCR2
Protein nameHepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
Hepatitis A virus cellular receptor 2
SynonymsTIM3
TIMD3
DescriptionFUNCTION: Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand . Regulates macrophage activation . Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance . In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse . In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses . Receptor for LGALS9 . Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged . Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 . In contrast, shown to suppress NK cell-mediated cytotoxicity . Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity). .

AccessionsE5RHN3
E5RFR4
ENST00000524219.2
A0A8Q3SJ15
ENST00000522593.6
ENST00000696901.1
ENST00000696902.1
A0A8V8TMM7
Q8TDQ0
ENST00000521665.2
ENST00000696900.1
ENST00000517358.3
ENST00000696897.1
ENST00000307851.9 [Q8TDQ0-1]
A0A8Q3SJ74
A0A8Q3SIX1
ENST00000696899.1 [Q8TDQ0-1]