NLRP2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NLRP2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP2 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0006954Biological processinflammatory response
GO_0050727Biological processregulation of inflammatory response
GO_0045087Biological processinnate immune response
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000781Cellular componentchromosome, telomeric region
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005737Cellular componentcytoplasm
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0032090Molecular functionPyrin domain binding

IV. Literature review

[source]
Gene nameNLRP2
Protein nameNACHT, LRR and PYD domains-containing protein 2
NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)
NACHT, LRR and PYD domains-containing protein 2 (NLR family pyrin domain containing 2)
SynonymsNALP2
PYPAF2
PAN1
NBS1
DescriptionFUNCTION: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases. .

AccessionsENST00000427260.6 [Q9NX02-5]
ENST00000618694.1 [Q9NX02-5]
ENST00000615586.4
ENST00000615023.4
ENST00000621165.4
ENST00000610346.4
ENST00000611476.4
ENST00000622042.4 [Q9NX02-1]
A0A0G2JLJ4
ENST00000620082.2
A0A0G2JPQ2
ENST00000543277.1
ENST00000613485.4 [Q9NX02-2]
ENST00000263437.10
ENST00000619281.4 [Q9NX02-1]
ENST00000381637.3
ENST00000616903.1 [Q9NX02-5]
ENST00000617384.4
ENST00000448584.7 [Q9NX02-1]
F5H5B1
ENST00000621151.4
ENST00000397169.3
ENST00000615173.1 [Q9NX02-1]
A0A0G2JLX3
ENST00000611410.4 [Q9NX02-1]
F5GYZ4
ENST00000543010.5 [Q9NX02-1]
K7EMK2
ENST00000622773.4 [Q9NX02-5]
ENST00000621594.4 [Q9NX02-1]
ENST00000616040.4 [Q9NX02-1]
ENST00000621200.4 [Q9NX02-1]
ENST00000618943.1 [Q9NX02-5]
ENST00000611642.1 [Q9NX02-5]
ENST00000611772.4 [Q9NX02-1]
ENST00000614389.4
ENST00000615197.4
ENST00000621057.4 [Q9NX02-4]
J3KN39
ENST00000618018.4 [Q9NX02-2]
ENST00000613825.4 [Q9NX02-1]
A0A0G2JP37
ENST00000617992.1
K7EJ90
ENST00000618731.4 [Q9NX02-2]
ENST00000618789.1 [Q9NX02-5]
ENST00000611888.4
ENST00000619885.4 [Q9NX02-2]
A0A0G2JNC8
ENST00000585500.5
ENST00000433772.6
ENST00000611676.4 [Q9NX02-2]
ENST00000618011.3
ENST00000339757.11 [Q9NX02-2]
ENST00000613062.4 [Q9NX02-1]
A0A0G2JMG8
ENST00000616079.4
ENST00000622864.4 [Q9NX02-2]
ENST00000537859.5 [Q9NX02-2]
ENST00000588107.5
K7ELX1
A0A0G2JPB6
ENST00000615391.4 [Q9NX02-1]
ENST00000621239.4 [Q9NX02-1]
ENST00000619454.4 [Q9NX02-1]
A0A0G2JLQ8
ENST00000622444.1 [Q9NX02-5]
ENST00000615521.4 [Q9NX02-1]
ENST00000612740.4
ENST00000618465.4
F5H7Q5
ENST00000616919.4 [Q9NX02-2]
ENST00000622600.4 [Q9NX02-2]
H0YH35
ENST00000610410.1
ENST00000613851.1 [Q9NX02-5]
ENST00000619664.4 [Q9NX02-1]
ENST00000588619.5
ENST00000539848.5
ENST00000540005.1
ENST00000611679.4 [Q9NX02-1]
ENST00000391721.8 [Q9NX02-4]
ENST00000622216.4 [Q9NX02-2]
Q9NX02
K7EPE6