IL18RAP | OmnibusX

Name	Number of supported studies	Average coverage
CD16-negative, CD56-bright natural killer cell, human	13 studies	23% ± 7%	Explore
natural killer cell	12 studies	24% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	21% ± 7%	Explore
mucosal invariant T cell	7 studies	23% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL18RAP at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	1964.00	578 / 578	59%	1.52	684 / 1155
stomach	78%	244.58	279 / 359	46%	1.16	132 / 286
kidney	63%	149.15	56 / 89	59%	1.56	530 / 901
liver	88%	225.03	200 / 226	28%	0.54	112 / 406
breast	77%	187.58	353 / 459	28%	0.62	309 / 1118
intestine	62%	292.90	595 / 966	41%	0.93	215 / 527
spleen	100%	5663.51	241 / 241	0%	0	0 / 0
adipose	92%	448.11	1109 / 1204	0%	0	0 / 0
bladder	57%	163.43	12 / 21	35%	0.86	174 / 504
peripheral blood	90%	16500.16	836 / 929	0%	0	0 / 0
uterus	37%	88.66	63 / 170	51%	1.36	232 / 459
lymph node	0%	0	0 / 0	83%	4.33	24 / 29
thymus	66%	138.98	433 / 653	15%	0.29	91 / 605
tonsil	0%	0	0 / 0	73%	2.12	33 / 45
esophagus	29%	60.97	416 / 1445	43%	1.06	79 / 183
prostate	62%	128.44	151 / 245	10%	0.19	48 / 502
pancreas	10%	18.42	32 / 328	51%	1.36	91 / 178
heart	41%	92.74	350 / 861	0%	0	0 / 0
skin	9%	13.12	157 / 1809	27%	0.68	127 / 472
blood vessel	29%	79.55	386 / 1335	0%	0	0 / 0
adrenal gland	19%	31.07	48 / 258	7%	0.23	15 / 230
ovary	13%	26.01	24 / 180	10%	0.15	43 / 430
brain	7%	10.31	184 / 2642	9%	0.19	60 / 705
muscle	5%	6.97	42 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0035655	Biological process	interleukin-18-mediated signaling pathway
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0006955	Biological process	immune response
GO_0006954	Biological process	inflammatory response
GO_0008283	Biological process	cell population proliferation
GO_0045954	Biological process	positive regulation of natural killer cell mediated cytotoxicity
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_0042119	Biological process	neutrophil activation
GO_0005886	Cellular component	plasma membrane
GO_0045092	Cellular component	interleukin-18 receptor complex
GO_0015026	Molecular function	coreceptor activity
GO_0042008	Molecular function	interleukin-18 receptor activity
GO_0003953	Molecular function	NAD+ nucleosidase activity
GO_0005515	Molecular function	protein binding
GO_0061809	Molecular function	NAD+ nucleotidase, cyclic ADP-ribose generating

Gene name	IL18RAP
Protein name	Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b) Interleukin 18 receptor accessory protein
Synonyms	IL1R7
Description	FUNCTION: Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation . May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). .
Accessions	ENST00000450855.1 ENST00000264260.6 [O95256-1] C9JLE2 O95256 ENST00000687160.1 [O95256-1] ENST00000409369.1 [O95256-2]

IL18RAP report