PJA2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	30 studies	30% ± 13%	Explore
fibroblast	26 studies	28% ± 12%	Explore
macrophage	25 studies	26% ± 10%	Explore
pericyte	25 studies	28% ± 11%	Explore
smooth muscle cell	24 studies	27% ± 11%	Explore
natural killer cell	21 studies	22% ± 7%	Explore
B cell	18 studies	24% ± 10%	Explore
classical monocyte	17 studies	27% ± 12%	Explore
astrocyte	15 studies	33% ± 13%	Explore
mast cell	14 studies	27% ± 11%	Explore
oligodendrocyte	14 studies	31% ± 12%	Explore
regulatory T cell	13 studies	19% ± 4%	Explore
monocyte	12 studies	25% ± 10%	Explore
endothelial cell of lymphatic vessel	12 studies	27% ± 10%	Explore
non-classical monocyte	12 studies	27% ± 15%	Explore
oligodendrocyte precursor cell	12 studies	30% ± 13%	Explore
glutamatergic neuron	11 studies	57% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	21% ± 6%	Explore
CD8-positive, alpha-beta T cell	11 studies	21% ± 5%	Explore
microglial cell	11 studies	31% ± 11%	Explore
T cell	10 studies	20% ± 5%	Explore
naive B cell	10 studies	22% ± 4%	Explore
GABAergic neuron	10 studies	48% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	22% ± 5%	Explore
endothelial cell of artery	9 studies	18% ± 3%	Explore
myofibroblast cell	9 studies	24% ± 9%	Explore
memory B cell	9 studies	19% ± 3%	Explore
myeloid cell	9 studies	27% ± 11%	Explore
CD4-positive, alpha-beta T cell	8 studies	23% ± 9%	Explore
conventional dendritic cell	8 studies	24% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	22% ± 7%	Explore
capillary endothelial cell	8 studies	18% ± 2%	Explore
neuron	8 studies	41% ± 17%	Explore
epithelial cell	8 studies	36% ± 17%	Explore
vein endothelial cell	8 studies	21% ± 11%	Explore
gamma-delta T cell	8 studies	24% ± 8%	Explore
mature NK T cell	7 studies	20% ± 5%	Explore
basal cell	7 studies	32% ± 12%	Explore
adipocyte	7 studies	24% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	19% ± 3%	Explore
dendritic cell	6 studies	31% ± 19%	Explore
leukocyte	6 studies	25% ± 6%	Explore
connective tissue cell	6 studies	28% ± 13%	Explore
amacrine cell	6 studies	34% ± 11%	Explore
interneuron	6 studies	50% ± 24%	Explore
ciliated cell	6 studies	30% ± 8%	Explore
endothelial cell of vascular tree	6 studies	27% ± 13%	Explore
type I pneumocyte	5 studies	23% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
abnormal cell	5 studies	25% ± 9%	Explore
retinal ganglion cell	5 studies	58% ± 22%	Explore
mucosal invariant T cell	5 studies	18% ± 4%	Explore
plasma cell	5 studies	29% ± 12%	Explore
cardiac muscle cell	5 studies	18% ± 1%	Explore
lymphocyte	5 studies	27% ± 9%	Explore
goblet cell	5 studies	29% ± 20%	Explore
alveolar macrophage	4 studies	23% ± 6%	Explore
type II pneumocyte	4 studies	21% ± 5%	Explore
pancreatic A cell	4 studies	41% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	22% ± 6%	Explore
retinal bipolar neuron	4 studies	27% ± 8%	Explore
glial cell	4 studies	25% ± 10%	Explore
granule cell	4 studies	32% ± 9%	Explore
retina horizontal cell	4 studies	29% ± 7%	Explore
Mueller cell	4 studies	29% ± 4%	Explore
T follicular helper cell	4 studies	20% ± 4%	Explore
neutrophil	4 studies	25% ± 8%	Explore
plasmacytoid dendritic cell	4 studies	22% ± 8%	Explore
ionocyte	3 studies	29% ± 8%	Explore
pancreatic D cell	3 studies	44% ± 31%	Explore
type B pancreatic cell	3 studies	56% ± 25%	Explore
exhausted T cell	3 studies	23% ± 7%	Explore
hematopoietic precursor cell	3 studies	39% ± 15%	Explore
plasmablast	3 studies	35% ± 14%	Explore
glomerular endothelial cell	3 studies	25% ± 4%	Explore
GABAergic interneuron	3 studies	36% ± 8%	Explore
progenitor cell	3 studies	21% ± 3%	Explore
club cell	3 studies	26% ± 7%	Explore
retinal pigment epithelial cell	3 studies	40% ± 17%	Explore
retinal rod cell	3 studies	19% ± 0%	Explore
mononuclear phagocyte	3 studies	25% ± 8%	Explore
OFF-bipolar cell	3 studies	31% ± 5%	Explore
ON-bipolar cell	3 studies	33% ± 4%	Explore
rod bipolar cell	3 studies	35% ± 6%	Explore
secretory cell	3 studies	28% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	22% ± 2%	Explore
muscle cell	3 studies	39% ± 21%	Explore
hematopoietic stem cell	3 studies	20% ± 4%	Explore
enteroendocrine cell	3 studies	26% ± 11%	Explore
adventitial cell	3 studies	17% ± 1%	Explore
chondrocyte	3 studies	25% ± 3%	Explore
double negative thymocyte	3 studies	23% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	39% ± 20%	Explore
peripheral blood	10 studies	26% ± 11%	Explore
lung	9 studies	28% ± 9%	Explore
eye	8 studies	26% ± 11%	Explore
bone marrow	4 studies	23% ± 12%	Explore
heart	4 studies	18% ± 2%	Explore
kidney	4 studies	19% ± 3%	Explore
adipose	4 studies	22% ± 2%	Explore
pancreas	3 studies	47% ± 22%	Explore
uterus	3 studies	32% ± 6%	Explore
intestine	3 studies	27% ± 9%	Explore
liver	3 studies	28% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	15873.49	2640 / 2642	100%	191.32	704 / 705
esophagus	100%	9719.16	1444 / 1445	99%	72.90	182 / 183
lung	100%	8262.10	577 / 578	99%	68.87	1144 / 1155
thymus	100%	8476.46	651 / 653	99%	130.19	598 / 605
breast	100%	9485.20	459 / 459	98%	103.39	1100 / 1118
prostate	100%	7807.00	244 / 245	99%	113.15	495 / 502
adrenal gland	100%	7498.64	258 / 258	98%	149.95	225 / 230
ovary	100%	10114.22	180 / 180	97%	41.22	419 / 430
kidney	99%	4804.01	88 / 89	97%	110.53	873 / 901
uterus	100%	11612.76	170 / 170	95%	57.21	434 / 459
skin	100%	7241.68	1801 / 1809	94%	94.20	443 / 472
pancreas	95%	3915.08	313 / 328	97%	68.80	173 / 178
intestine	100%	10009.09	966 / 966	93%	46.75	488 / 527
stomach	95%	6041.94	341 / 359	95%	54.36	273 / 286
liver	98%	4355.01	222 / 226	92%	48.75	374 / 406
bladder	100%	11870.48	21 / 21	89%	42.65	447 / 504
blood vessel	100%	17995.25	1335 / 1335	0%	0	0 / 0
spleen	100%	5787.12	241 / 241	0%	0	0 / 0
adipose	100%	10269.36	1203 / 1204	0%	0	0 / 0
muscle	99%	5094.87	792 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	65.67	43 / 45
heart	91%	5720.38	786 / 861	0%	0	0 / 0
peripheral blood	87%	6351.84	811 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	43.73	25 / 29
eye	0%	0	0 / 0	79%	42.24	63 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0006954	Biological process	inflammatory response
GO_0045087	Biological process	innate immune response
GO_0007616	Biological process	long-term memory
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0043030	Biological process	regulation of macrophage activation
GO_1900745	Biological process	positive regulation of p38MAPK cascade
GO_0034137	Biological process	positive regulation of toll-like receptor 2 signaling pathway
GO_0010738	Biological process	regulation of protein kinase A signaling
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005886	Cellular component	plasma membrane
GO_0034451	Cellular component	centriolar satellite
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005813	Cellular component	centrosome
GO_0045111	Cellular component	intermediate filament cytoskeleton
GO_0000139	Cellular component	Golgi membrane
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0036064	Cellular component	ciliary basal body
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0034237	Molecular function	protein kinase A regulatory subunit binding
GO_0034236	Molecular function	protein kinase A catalytic subunit binding
GO_0046872	Molecular function	metal ion binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PJA2
Protein name	E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)
Synonyms	KIAA0438 RNF131
Description	FUNCTION: Has E2-dependent E3 ubiquitin-protein ligase activity . Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes . Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype . Plays a role in ciliogenesis by ubiquitinating OFD1 . .
Accessions	ENST00000361189.7 [O43164-1] O43164 ENST00000361557.4 [O43164-1]

PJA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review