OLR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002376Biological processimmune system process
GO_0006954Biological processinflammatory response
GO_0042157Biological processlipoprotein metabolic process
GO_0016192Biological processvesicle-mediated transport
GO_0006508Biological processproteolysis
GO_0008015Biological processblood circulation
GO_0007159Biological processleukocyte cell-cell adhesion
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0070821Cellular componenttertiary granule membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030246Molecular functioncarbohydrate binding
GO_0042802Molecular functionidentical protein binding
GO_0005041Molecular functionlow-density lipoprotein particle receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOLR1
Protein nameOxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]
Oxidized low density lipoprotein receptor 1 (cDNA, FLJ79252, weakly similar to Oxidized low-density lipoprotein receptor 1)
Oxidized low density lipoprotein receptor 1
Oxidized low-density lipoprotein receptor 1 (Lectin-like oxidized LDL receptor 1) (Lectin-type oxidized LDL receptor 1)
SynonymsCLEC8A
LOX1
DescriptionFUNCTION: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. .; FUNCTION: (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis. .

AccessionsENST00000543414.1
P78380
ENST00000339968
B7ZAN8
ENST00000544577.5
ENST00000432556.6 [P78380-2]
F5H001
F5H7N8
ENST00000538745.5
F5H3G7
J3QTI8
F5GZH1
ENST00000309539.8 [P78380-1]
ENST00000543993.5
F5H0N6
ENST00000538873.1
ENST00000545927.5 [P78380-3]
ENST00000539518.5