TMED2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001893Biological processmaternal placenta development
GO_0035459Biological processvesicle cargo loading
GO_0060717Biological processchorion development
GO_0034260Biological processnegative regulation of GTPase activity
GO_0006954Biological processinflammatory response
GO_0072659Biological processprotein localization to plasma membrane
GO_2000638Biological processregulation of SREBP signaling pathway
GO_0001947Biological processheart looping
GO_0090158Biological processendoplasmic reticulum membrane organization
GO_0032525Biological processsomite rostral/caudal axis specification
GO_0010628Biological processpositive regulation of gene expression
GO_0035264Biological processmulticellular organism growth
GO_0006886Biological processintracellular protein transport
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0036499Biological processPERK-mediated unfolded protein response
GO_0007030Biological processGolgi organization
GO_0036342Biological processpost-anal tail morphogenesis
GO_0060716Biological processlabyrinthine layer blood vessel development
GO_0001843Biological processneural tube closure
GO_0060670Biological processbranching involved in labyrinthine layer morphogenesis
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_1903912Biological processnegative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO_1905069Biological processallantois development
GO_0048205Biological processCOPI coating of Golgi vesicle
GO_0072595Biological processmaintenance of protein localization in organelle
GO_0048208Biological processCOPII vesicle coating
GO_0009306Biological processprotein secretion
GO_0030137Cellular componentCOPI-coated vesicle
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0042589Cellular componentzymogen granule membrane
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0030134Cellular componentCOPII-coated ER to Golgi transport vesicle
GO_0030133Cellular componenttransport vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0030663Cellular componentCOPI-coated vesicle membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0005119Molecular functionsmoothened binding
GO_0038024Molecular functioncargo receptor activity
GO_0005109Molecular functionfrizzled binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMED2
Protein nameTransmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)
RNP24 protein (Transmembrane emp24 domain trafficking protein 2, isoform CRA_a) (cDNA, FLJ93436, Homo sapiens coated vesicle membrane protein (RNP24), mRNA)
Transmembrane p24 trafficking protein 2
SynonymshCG_1743563
RNP24
DescriptionFUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. .

AccessionsENST00000509052.2
F5GX39
Q15363
ENST00000262225.8
Q6FHT8
E7EQ72
ENST00000438031.2