Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 95% | 9080.29 | 2516 / 2642 | 75% | 6.13 | 530 / 705 |
| prostate | 70% | 609.22 | 172 / 245 | 77% | 2.41 | 388 / 502 |
| lung | 56% | 387.67 | 322 / 578 | 45% | 0.98 | 519 / 1155 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 9.19 | 26 / 29 |
| spleen | 89% | 635.93 | 215 / 241 | 0% | 0 | 0 / 0 |
| adrenal gland | 12% | 111.17 | 31 / 258 | 66% | 19.59 | 152 / 230 |
| intestine | 55% | 491.07 | 534 / 966 | 21% | 0.51 | 110 / 527 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 1.74 | 31 / 45 |
| pancreas | 0% | 0 | 0 / 328 | 69% | 1.87 | 122 / 178 |
| peripheral blood | 65% | 1371.54 | 606 / 929 | 0% | 0 | 0 / 0 |
| uterus | 8% | 39.37 | 14 / 170 | 51% | 1.57 | 235 / 459 |
| esophagus | 6% | 27.35 | 84 / 1445 | 50% | 1.27 | 92 / 183 |
| bladder | 33% | 165.81 | 7 / 21 | 21% | 0.59 | 104 / 504 |
| kidney | 16% | 131.79 | 14 / 89 | 38% | 0.73 | 344 / 901 |
| stomach | 19% | 90.58 | 69 / 359 | 32% | 0.72 | 92 / 286 |
| breast | 3% | 12.53 | 12 / 459 | 48% | 1.08 | 535 / 1118 |
| skin | 6% | 30.86 | 104 / 1809 | 44% | 1.98 | 208 / 472 |
| thymus | 7% | 64.74 | 47 / 653 | 20% | 4.24 | 119 / 605 |
| eye | 0% | 0 | 0 / 0 | 21% | 0.55 | 17 / 80 |
| ovary | 7% | 30.23 | 12 / 180 | 10% | 0.20 | 41 / 430 |
| liver | 10% | 47.47 | 23 / 226 | 5% | 0.12 | 22 / 406 |
| adipose | 4% | 17.88 | 43 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 10.55 | 19 / 1335 | 0% | 0 | 0 / 0 |
| heart | 0% | 1.72 | 3 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007616 | Biological process | long-term memory |
| GO_0002735 | Biological process | positive regulation of myeloid dendritic cell cytokine production |
| GO_0007165 | Biological process | signal transduction |
| GO_0045670 | Biological process | regulation of osteoclast differentiation |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0043011 | Biological process | myeloid dendritic cell differentiation |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0033081 | Biological process | regulation of T cell differentiation in thymus |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0001650 | Cellular component | fibrillar center |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0009931 | Molecular function | calcium-dependent protein serine/threonine kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0004683 | Molecular function | calmodulin-dependent protein kinase activity |
| GO_0005516 | Molecular function | calmodulin binding |
| Gene name | CAMK4 |
| Protein name | Calcium/calmodulin dependent protein kinase IV Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) |
| Synonyms | CAMKIV CAMK CAMK-GR |
| Description | FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. . |
| Accessions | D6RE65 ENST00000514007.5 ENST00000508074.5 Q16566 ENST00000504544.5 ENST00000282356.9 D6RCD6 D6REY7 ENST00000515231.5 ENST00000512453.5 |
