NFATC4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NFATC4 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0071285Biological processcellular response to lithium ion
GO_0031547Biological processbrain-derived neurotrophic factor receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0007507Biological processheart development
GO_0034644Biological processcellular response to UV
GO_2000297Biological processnegative regulation of synapse maturation
GO_0048813Biological processdendrite morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007616Biological processlong-term memory
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0001816Biological processcytokine production
GO_0033173Biological processcalcineurin-NFAT signaling cascade
GO_0097084Biological processvascular associated smooth muscle cell development
GO_0045333Biological processcellular respiration
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0060291Biological processlong-term synaptic potentiation
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0051402Biological processneuron apoptotic process
GO_0001569Biological processbranching involved in blood vessel morphogenesis
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0060074Biological processsynapse maturation
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0050774Biological processnegative regulation of dendrite morphogenesis
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042975Molecular functionperoxisome proliferator activated receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFATC4
Protein nameNuclear factor of activated T cells 4
Alternative protein NFATC4
Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)
SynonymsNFAT3
DescriptionFUNCTION: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems . Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 . Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) . Plays a role in adipocyte differentiation . May be involved in myoblast differentiation into myotubes . Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription . Binds to PPARG gene promoter and regulates its activity . Binds to PPARG and REG3G gene promoters (By similarity). .

AccessionsENST00000555167.1 [Q14934-20]
G3V4K1
ENST00000644583.1 [Q14934-23]
ENST00000422617.7 [Q14934-10]
ENST00000642302.2 [Q14934-1]
ENST00000642571.1 [Q14934-4]
ENST00000554591.5 [Q14934-11]
ENST00000644376.1 [Q14934-3]
ENST00000646023.1 [Q14934-10]
ENST00000557451.5 [Q14934-13]
ENST00000556279.5 [Q14934-4]
ENST00000646650.1 [Q14934-11]
ENST00000645116.1 [Q14934-5]
ENST00000554903.1
G3V5H0
ENST00000553879.5 [Q14934-12]
ENST00000645795.1 [Q14934-20]
ENST00000643468.1 [Q14934-12]
ENST00000553708.5 [Q14934-8]
ENST00000644758.1 [Q14934-6]
ENST00000413692.6 [Q14934-3]
ENST00000642182.1 [Q14934-18]
ENST00000646364.1 [Q14934-15]
ENST00000647017.1 [Q14934-22]
ENST00000646652.1 [Q14934-24]
ENST00000644025.1 [Q14934-16]
ENST00000645397.1 [Q14934-19]
ENST00000644182.1 [Q14934-12]
ENST00000424781.6 [Q14934-7]
ENST00000555393.5 [Q14934-23]
ENST00000643679.1 [Q14934-8]
ENST00000554779.1
ENST00000647345.1 [Q14934-17]
Q14934
ENST00000556169.5 [Q14934-17]
ENST00000555802.1 [Q14934-22]
ENST00000555590.5 [Q14934-6]
ENST00000250373.9 [Q14934-1]
ENST00000554344.5 [Q14934-12]
ENST00000643941.1 [Q14934-9]
G3V4U6
ENST00000555453.5 [Q14934-9]
L0R8A8
ENST00000554050.5 [Q14934-16]
ENST00000642650.1 [Q14934-13]
ENST00000642423.1 [Q14934-14]
ENST00000557767.5 [Q14934-24]
ENST00000557674.1
ENST00000554661.5 [Q14934-18]
ENST00000553469.5 [Q14934-14]
ENST00000556759.5 [Q14934-19]
ENST00000554473.5 [Q14934-21]
ENST00000645587.1 [Q14934-21]
ENST00000644166.1 [Q14934-7]
ENST00000554966.5 [Q14934-15]
ENST00000539237.6 [Q14934-5]