CCL17 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCL17 at tissue level.

III. Associated gene sets

GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_0006954Biological processinflammatory response
GO_0006935Biological processchemotaxis
GO_0043547Biological processpositive regulation of GTPase activity
GO_0060326Biological processcell chemotaxis
GO_0007267Biological processcell-cell signaling
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0048020Molecular functionCCR chemokine receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0008009Molecular functionchemokine activity

IV. Literature review

[source]
Gene nameCCL17
Protein nameC-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
SynonymsTARC
SCYA17
DescriptionFUNCTION: Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes . Acts by binding to CCR4 at T-cell surface . Mediates GM-CSF/CSF2-driven pain and inflammation . In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (By similarity). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity). .

AccessionsQ92583
ENST00000219244.9
ENST00000616880.1