Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| lung | 20 studies | 38% ± 16% | |
| brain | 14 studies | 32% ± 15% | |
| intestine | 10 studies | 24% ± 10% | |
| kidney | 10 studies | 27% ± 9% | |
| peripheral blood | 8 studies | 25% ± 8% | |
| eye | 7 studies | 35% ± 13% | |
| liver | 6 studies | 37% ± 15% | |
| heart | 5 studies | 29% ± 4% | |
| uterus | 5 studies | 45% ± 17% | |
| adipose | 5 studies | 34% ± 14% | |
| breast | 5 studies | 33% ± 14% | |
| esophagus | 4 studies | 39% ± 17% | |
| lymph node | 4 studies | 23% ± 6% | |
| prostate | 4 studies | 30% ± 5% | |
| pancreas | 3 studies | 37% ± 10% | |
| skin | 3 studies | 34% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 11825.84 | 1445 / 1445 | 100% | 151.91 | 183 / 183 |
| ovary | 100% | 12782.88 | 180 / 180 | 100% | 64.48 | 430 / 430 |
| lung | 100% | 8260.86 | 577 / 578 | 100% | 125.52 | 1154 / 1155 |
| intestine | 100% | 6531.59 | 966 / 966 | 99% | 66.31 | 523 / 527 |
| thymus | 100% | 9574.62 | 653 / 653 | 99% | 100.92 | 599 / 605 |
| bladder | 100% | 12944.52 | 21 / 21 | 99% | 77.82 | 499 / 504 |
| stomach | 100% | 7741.99 | 359 / 359 | 99% | 69.87 | 283 / 286 |
| kidney | 100% | 7226.89 | 89 / 89 | 99% | 76.80 | 891 / 901 |
| brain | 99% | 3885.58 | 2612 / 2642 | 100% | 74.83 | 703 / 705 |
| breast | 100% | 7303.24 | 459 / 459 | 99% | 71.17 | 1102 / 1118 |
| uterus | 100% | 7417.59 | 170 / 170 | 98% | 108.97 | 451 / 459 |
| prostate | 100% | 7157.24 | 245 / 245 | 98% | 53.85 | 493 / 502 |
| skin | 100% | 10764.55 | 1808 / 1809 | 97% | 77.13 | 457 / 472 |
| adrenal gland | 100% | 6456.37 | 258 / 258 | 92% | 40.91 | 212 / 230 |
| liver | 100% | 3600.80 | 226 / 226 | 91% | 40.68 | 370 / 406 |
| pancreas | 88% | 2316.03 | 289 / 328 | 99% | 68.07 | 176 / 178 |
| adipose | 100% | 8316.75 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5499.34 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 162.89 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 29.73 | 1 / 1 |
| blood vessel | 100% | 8107.19 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 4431.64 | 800 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 4858.22 | 836 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 39.46 | 27 / 29 |
| peripheral blood | 93% | 4125.77 | 862 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 86% | 36.88 | 69 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045454 | Biological process | cell redox homeostasis |
| GO_0042149 | Biological process | cellular response to glucose starvation |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_2000352 | Biological process | negative regulation of endothelial cell apoptotic process |
| GO_0071466 | Biological process | cellular response to xenobiotic stimulus |
| GO_0006954 | Biological process | inflammatory response |
| GO_0045995 | Biological process | regulation of embryonic development |
| GO_0002931 | Biological process | response to ischemia |
| GO_0046326 | Biological process | positive regulation of glucose import |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
| GO_0046223 | Biological process | aflatoxin catabolic process |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0071498 | Biological process | cellular response to fluid shear stress |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0110076 | Biological process | negative regulation of ferroptosis |
| GO_1902037 | Biological process | negative regulation of hematopoietic stem cell differentiation |
| GO_1902176 | Biological process | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| GO_0036499 | Biological process | PERK-mediated unfolded protein response |
| GO_2000121 | Biological process | regulation of removal of superoxide radicals |
| GO_0045088 | Biological process | regulation of innate immune response |
| GO_0030968 | Biological process | endoplasmic reticulum unfolded protein response |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0071280 | Biological process | cellular response to copper ion |
| GO_0034599 | Biological process | cellular response to oxidative stress |
| GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
| GO_1900038 | Biological process | negative regulation of cellular response to hypoxia |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_1903788 | Biological process | positive regulation of glutathione biosynthetic process |
| GO_2000379 | Biological process | positive regulation of reactive oxygen species metabolic process |
| GO_0030194 | Biological process | positive regulation of blood coagulation |
| GO_1900407 | Biological process | regulation of cellular response to oxidative stress |
| GO_1904753 | Biological process | negative regulation of vascular associated smooth muscle cell migration |
| GO_0010499 | Biological process | proteasomal ubiquitin-independent protein catabolic process |
| GO_1904294 | Biological process | positive regulation of ERAD pathway |
| GO_0010667 | Biological process | negative regulation of cardiac muscle cell apoptotic process |
| GO_0071499 | Biological process | cellular response to laminar fluid shear stress |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO_0140467 | Biological process | integrated stress response signaling |
| GO_0071456 | Biological process | cellular response to hypoxia |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_1904385 | Biological process | cellular response to angiotensin |
| GO_0016592 | Cellular component | mediator complex |
| GO_0032993 | Cellular component | protein-DNA complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043228 | Cellular component | non-membrane-bounded organelle |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0001221 | Molecular function | transcription coregulator binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0140693 | Molecular function | molecular condensate scaffold activity |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NFE2L2 |
| Protein name | NFE2 like bZIP transcription factor 2 Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2) Nuclear factor erythroid 2-related factor 2 Nuclear factor erythroid-derived 2-like 2 transcript variant 1 |
| Synonyms | NRF2 |
| Description | FUNCTION: Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles . In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex . In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes . The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes . May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region . Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses . Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism . . |
| Accessions | ENST00000699346.1 ENST00000699301.1 A0A8V8TNJ6 ENST00000699350.1 ENST00000464747.5 [Q16236-2] ENST00000699300.1 ENST00000699352.1 ENST00000458603.2 ENST00000699342.1 ENST00000699405.1 A0A8V8TN51 A0A8V8TPL6 ENST00000699328.1 [Q16236-2] E2I973 ENST00000699304.1 ENST00000699435.1 ENST00000699348.1 H7C498 ENST00000699297.1 ENST00000448782.6 [Q16236-2] ENST00000699351.1 [Q16236-2] ENST00000421929.5 A0A8V8TPC8 A0A8V8TPA8 ENST00000699223.1 ENST00000699264.1 ENST00000699343.1 [Q16236-2] ENST00000699409.1 [Q16236-2] A0A8V8TPI5 ENST00000699303.1 ENST00000699411.1 ENST00000699309.1 A0A8V8TNS1 ENST00000699432.1 ENST00000699410.1 A0A8V8TPN5 ENST00000699296.1 A0A8V8TNI6 ENST00000699302.1 ENST00000699224.1 K7ER33 ENST00000699308.1 ENST00000699408.1 [Q16236-2] ENST00000421929.6 [Q16236-2] C9J0Y1 A0A8V8TNQ8 A0A8V8TPF4 A0A8V8TND9 A0A8V8TN31 A0A8V8TNM5 ENST00000699347.1 ENST00000699434.1 [Q16236-2] K7EIW5 ENST00000699299.1 ENST00000699307.1 ENST00000397063.9 [Q16236-2] ENST00000699327.1 ENST00000699431.1 ENST00000699353.1 A0A8V8TNM0 A0A8V8TQ20 ENST00000699404.1 ENST00000699220.1 ENST00000699305.1 ENST00000699345.1 ENST00000699407.1 ENST00000699331.1 ENST00000588123.2 ENST00000586532.6 ENST00000699298.1 Q16236 ENST00000699412.1 ENST00000699344.1 A0A8V8TN40 ENST00000448782.5 A0A8V8TPF0 ENST00000446151.6 [Q16236-3] A0A8V8TN14 A0A8V8TPX0 A0A8V8TN41 A0A8V8TPT8 ENST00000699265.1 ENST00000699406.1 A0A8V8TN85 A0A8V8TPM0 ENST00000397062.8 [Q16236-1] ENST00000699330.1 [Q16236-2] C9J1A8 |
