Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 18 studies | 51% ± 27% | |
| CD16-negative, CD56-bright natural killer cell, human | 10 studies | 24% ± 5% | |
| mucosal invariant T cell | 7 studies | 22% ± 3% | |
| innate lymphoid cell | 7 studies | 26% ± 10% | |
| endothelial cell | 6 studies | 23% ± 1% | |
| capillary endothelial cell | 4 studies | 18% ± 1% | |
| plasmacytoid dendritic cell | 4 studies | 21% ± 5% | |
| dendritic cell | 3 studies | 18% ± 2% | |
| group 3 innate lymphoid cell | 3 studies | 34% ± 11% |
Insufficient scRNA-seq data for expression of IL18R1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 4787.30 | 578 / 578 | 92% | 4.30 | 1058 / 1155 |
| stomach | 97% | 646.58 | 347 / 359 | 86% | 3.26 | 245 / 286 |
| esophagus | 88% | 534.32 | 1278 / 1445 | 90% | 5.21 | 165 / 183 |
| kidney | 92% | 737.83 | 82 / 89 | 85% | 6.25 | 769 / 901 |
| breast | 99% | 1061.72 | 453 / 459 | 77% | 2.37 | 863 / 1118 |
| bladder | 100% | 792.76 | 21 / 21 | 76% | 2.52 | 382 / 504 |
| uterus | 93% | 493.24 | 158 / 170 | 80% | 3.34 | 366 / 459 |
| liver | 100% | 629.63 | 226 / 226 | 71% | 2.56 | 288 / 406 |
| thymus | 90% | 441.27 | 587 / 653 | 80% | 4.87 | 487 / 605 |
| intestine | 89% | 796.89 | 859 / 966 | 78% | 2.80 | 410 / 527 |
| prostate | 93% | 671.60 | 227 / 245 | 71% | 1.61 | 357 / 502 |
| skin | 93% | 473.96 | 1680 / 1809 | 40% | 1.12 | 187 / 472 |
| pancreas | 28% | 85.77 | 91 / 328 | 95% | 5.31 | 169 / 178 |
| adrenal gland | 83% | 388.93 | 213 / 258 | 24% | 0.74 | 56 / 230 |
| ovary | 41% | 150.82 | 74 / 180 | 61% | 1.52 | 264 / 430 |
| spleen | 100% | 3424.17 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1283.20 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 6548.93 | 912 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 5.36 | 44 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 7.99 | 28 / 29 |
| heart | 83% | 465.92 | 717 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 59% | 269.81 | 782 / 1335 | 0% | 0 | 0 / 0 |
| brain | 27% | 108.16 | 723 / 2642 | 23% | 0.50 | 162 / 705 |
| muscle | 16% | 44.53 | 128 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.09 | 5 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901224 | Biological process | positive regulation of non-canonical NF-kappaB signal transduction |
| GO_2000556 | Biological process | positive regulation of T-helper 1 cell cytokine production |
| GO_0006954 | Biological process | inflammatory response |
| GO_0045063 | Biological process | T-helper 1 cell differentiation |
| GO_0007165 | Biological process | signal transduction |
| GO_0030101 | Biological process | natural killer cell activation |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0006955 | Biological process | immune response |
| GO_0035655 | Biological process | interleukin-18-mediated signaling pathway |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0120163 | Biological process | negative regulation of cold-induced thermogenesis |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045092 | Cellular component | interleukin-18 receptor complex |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0003953 | Molecular function | NAD+ nucleosidase activity |
| GO_0004908 | Molecular function | interleukin-1 receptor activity |
| GO_0042007 | Molecular function | interleukin-18 binding |
| GO_0042008 | Molecular function | interleukin-18 receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0061809 | Molecular function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| Gene name | IL18R1 |
| Protein name | IL18R1 protein IL18Ralpha2 splice variant Interleukin 18 receptor 1 Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a) |
| Synonyms | IL1RRP |
| Description | FUNCTION: Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B . Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells . Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). . |
| Accessions | ENST00000410040.5 A0A089VKP9 Q86YL8 ENST00000677287.1 A0A089VIW4 B7ZKV7 ENST00000409599.5 Q13478 ENST00000233957.7 |
