PLD3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	43 studies	45% ± 17%	Explore
fibroblast	43 studies	35% ± 19%	Explore
endothelial cell	26 studies	30% ± 12%	Explore
classical monocyte	23 studies	32% ± 14%	Explore
monocyte	17 studies	29% ± 13%	Explore
connective tissue cell	17 studies	41% ± 24%	Explore
pericyte	15 studies	30% ± 11%	Explore
smooth muscle cell	15 studies	32% ± 15%	Explore
myofibroblast cell	14 studies	39% ± 17%	Explore
myeloid cell	14 studies	40% ± 19%	Explore
basal cell	13 studies	37% ± 20%	Explore
epithelial cell	13 studies	41% ± 24%	Explore
type II pneumocyte	12 studies	47% ± 22%	Explore
conventional dendritic cell	11 studies	33% ± 18%	Explore
astrocyte	11 studies	29% ± 12%	Explore
type I pneumocyte	10 studies	37% ± 21%	Explore
GABAergic neuron	10 studies	44% ± 22%	Explore
non-classical monocyte	10 studies	26% ± 9%	Explore
neuron	10 studies	49% ± 21%	Explore
glutamatergic neuron	10 studies	52% ± 22%	Explore
microglial cell	10 studies	28% ± 6%	Explore
oligodendrocyte precursor cell	10 studies	30% ± 12%	Explore
natural killer cell	10 studies	17% ± 2%	Explore
oligodendrocyte	10 studies	31% ± 10%	Explore
plasma cell	9 studies	33% ± 14%	Explore
ciliated cell	9 studies	34% ± 14%	Explore
alveolar macrophage	8 studies	43% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	19% ± 3%	Explore
mesothelial cell	8 studies	43% ± 21%	Explore
dendritic cell	8 studies	33% ± 16%	Explore
endothelial cell of lymphatic vessel	8 studies	25% ± 10%	Explore
mast cell	8 studies	33% ± 19%	Explore
capillary endothelial cell	7 studies	24% ± 10%	Explore
abnormal cell	7 studies	32% ± 14%	Explore
secretory cell	6 studies	35% ± 20%	Explore
mononuclear phagocyte	6 studies	35% ± 20%	Explore
progenitor cell	6 studies	38% ± 28%	Explore
endothelial cell of artery	6 studies	32% ± 16%	Explore
vein endothelial cell	6 studies	29% ± 18%	Explore
amacrine cell	6 studies	37% ± 19%	Explore
retinal ganglion cell	6 studies	66% ± 32%	Explore
adipocyte	6 studies	32% ± 21%	Explore
enteroendocrine cell	5 studies	40% ± 23%	Explore
club cell	5 studies	42% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 2%	Explore
regulatory T cell	5 studies	17% ± 1%	Explore
interneuron	5 studies	49% ± 23%	Explore
pancreatic A cell	4 studies	59% ± 21%	Explore
plasmablast	4 studies	30% ± 18%	Explore
leukocyte	4 studies	27% ± 3%	Explore
retinal bipolar neuron	4 studies	32% ± 15%	Explore
retina horizontal cell	4 studies	40% ± 17%	Explore
adventitial cell	4 studies	31% ± 16%	Explore
intermediate monocyte	4 studies	41% ± 14%	Explore
goblet cell	4 studies	25% ± 7%	Explore
ionocyte	3 studies	21% ± 5%	Explore
type B pancreatic cell	3 studies	43% ± 11%	Explore
hematopoietic precursor cell	3 studies	30% ± 8%	Explore
glomerular endothelial cell	3 studies	22% ± 2%	Explore
podocyte	3 studies	62% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	32% ± 9%	Explore
neural crest cell	3 studies	21% ± 6%	Explore
GABAergic interneuron	3 studies	35% ± 3%	Explore
glial cell	3 studies	36% ± 17%	Explore
granule cell	3 studies	32% ± 12%	Explore
GABAergic amacrine cell	3 studies	38% ± 16%	Explore
mucosal invariant T cell	3 studies	17% ± 1%	Explore
tissue-resident macrophage	3 studies	56% ± 20%	Explore
Mueller cell	3 studies	27% ± 4%	Explore
OFF-bipolar cell	3 studies	44% ± 35%	Explore
ON-bipolar cell	3 studies	47% ± 35%	Explore
rod bipolar cell	3 studies	34% ± 9%	Explore
endothelial cell of vascular tree	3 studies	25% ± 6%	Explore
myoepithelial cell	3 studies	33% ± 7%	Explore
inflammatory macrophage	3 studies	37% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	31% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	20% ± 4%	Explore
hematopoietic stem cell	3 studies	20% ± 5%	Explore
gamma-delta T cell	3 studies	20% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	30% ± 13%	Explore
brain	16 studies	37% ± 17%	Explore
peripheral blood	11 studies	20% ± 3%	Explore
intestine	7 studies	32% ± 17%	Explore
kidney	7 studies	22% ± 8%	Explore
eye	7 studies	27% ± 10%	Explore
adipose	5 studies	25% ± 11%	Explore
pancreas	4 studies	37% ± 19%	Explore
placenta	4 studies	32% ± 8%	Explore
uterus	3 studies	30% ± 12%	Explore
liver	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	15568.04	258 / 258	100%	630.96	230 / 230
ovary	100%	15275.66	180 / 180	100%	228.78	430 / 430
brain	100%	18800.60	2637 / 2642	100%	164.53	705 / 705
thymus	100%	10744.30	652 / 653	100%	315.67	603 / 605
skin	100%	10223.67	1807 / 1809	99%	267.47	469 / 472
prostate	100%	11580.13	245 / 245	99%	154.22	498 / 502
kidney	100%	9544.34	89 / 89	99%	156.96	893 / 901
uterus	100%	11859.88	170 / 170	99%	230.21	454 / 459
esophagus	100%	8485.06	1445 / 1445	99%	113.92	181 / 183
pancreas	100%	6446.34	328 / 328	99%	189.74	176 / 178
lung	100%	15740.93	578 / 578	99%	289.71	1142 / 1155
breast	100%	11531.98	459 / 459	98%	154.77	1100 / 1118
intestine	100%	9501.13	966 / 966	98%	108.03	515 / 527
stomach	100%	7831.24	359 / 359	98%	115.95	279 / 286
bladder	100%	9788.52	21 / 21	97%	169.56	489 / 504
liver	100%	5220.36	225 / 226	97%	103.69	394 / 406
adipose	100%	13033.39	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	288.03	80 / 80
lymph node	0%	0	0 / 0	100%	172.17	29 / 29
spleen	100%	16478.90	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	154.32	45 / 45
ureter	0%	0	0 / 0	100%	81.58	1 / 1
blood vessel	100%	13936.44	1333 / 1335	0%	0	0 / 0
heart	99%	9473.99	852 / 861	0%	0	0 / 0
muscle	97%	4596.80	777 / 803	0%	0	0 / 0
peripheral blood	85%	4246.88	789 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002376	Biological process	immune system process
GO_0014902	Biological process	myotube differentiation
GO_0006259	Biological process	DNA metabolic process
GO_0006954	Biological process	inflammatory response
GO_1900015	Biological process	regulation of cytokine production involved in inflammatory response
GO_0031901	Cellular component	early endosome membrane
GO_0043202	Cellular component	lysosomal lumen
GO_0000139	Cellular component	Golgi membrane
GO_0070062	Cellular component	extracellular exosome
GO_0031902	Cellular component	late endosome membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0045145	Molecular function	single-stranded DNA 5'-3' DNA exonuclease activity
GO_0005515	Molecular function	protein binding
GO_0004630	Molecular function	phospholipase D activity

IV. Literature review

[source]

Gene name	PLD3
Protein name	5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase 3) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Phospholipase D3) Phospholipase D family member 3 5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Phospholipase D3) (PLD 3)
Synonyms
Description	FUNCTION: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) . Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation . Plays a role in lysosomal homeostasis . Involved in the regulation of endosomal protein sorting . .
Accessions	ENST00000600948.5 ENST00000392032.6 ENST00000700619.1 ENST00000700637.1 A0A8V8TQH4 ENST00000599353.1 M0QX99 ENST00000409735.9 ENST00000700633.1 ENST00000700620.1 ENST00000596682.5 M0QX50 ENST00000409587.5 ENST00000700630.1 ENST00000492243.1 ENST00000409419.5 M0R3G9 M0QY94 ENST00000700623.1 ENST00000700628.1 ENST00000599685.5 ENST00000598962.5 A0A0A0MS28 M0R2E7 M0R2W7 A0A8V8TRD4 ENST00000356508.9 ENST00000602131.5 ENST00000486134.1 ENST00000700634.1 A0A8V8TQH6 ENST00000700638.1 M0QYJ4 ENST00000359274.5 ENST00000700626.1 Q8IV08 ENST00000700624.1 M0R1F7 ENST00000700631.1 ENST00000700616.1 ENST00000700632.1 A0A8V8TPY8 ENST00000409281.5 ENST00000700621.1 ENST00000700617.1 E2QRG1 ENST00000594908.5 M0QZK2 ENST00000700625.1 ENST00000700618.1

PLD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review