PRKCQ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0050870Biological processpositive regulation of T cell activation
GO_0070233Biological processnegative regulation of T cell apoptotic process
GO_0006954Biological processinflammatory response
GO_1904355Biological processpositive regulation of telomere capping
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0001558Biological processregulation of cell growth
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_2000318Biological processpositive regulation of T-helper 17 type immune response
GO_0035739Biological processCD4-positive, alpha-beta T cell proliferation
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0090330Biological processregulation of platelet aggregation
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_2000570Biological processpositive regulation of T-helper 2 cell activation
GO_0035556Biological processintracellular signal transduction
GO_0051973Biological processpositive regulation of telomerase activity
GO_2000563Biological processpositive regulation of CD4-positive, alpha-beta T cell proliferation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006468Biological processprotein phosphorylation
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0060326Biological processcell chemotaxis
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0007411Biological processaxon guidance
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0034451Cellular componentcentriolar satellite
GO_0016235Cellular componentaggresome
GO_0005829Cellular componentcytosol
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKCQ
Protein nameProtein kinase C theta type (EC 2.7.11.13) (nPKC-theta)
SynonymsPRKCT
DescriptionFUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity . .

AccessionsENST00000263125.10 [Q04759-1]
ENST00000539722.5 [Q04759-3]
Q04759
ENST00000397176.6 [Q04759-2]