DHX9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_2000373Biological processpositive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0006954Biological processinflammatory response
GO_0050434Biological processpositive regulation of viral transcription
GO_0006260Biological processDNA replication
GO_0045089Biological processpositive regulation of innate immune response
GO_0039695Biological processDNA-templated viral transcription
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0032741Biological processpositive regulation of interleukin-18 production
GO_0045740Biological processpositive regulation of DNA replication
GO_0070934Biological processCRD-mediated mRNA stabilization
GO_0070922Biological processRISC complex assembly
GO_0010501Biological processRNA secondary structure unwinding
GO_0048511Biological processrhythmic process
GO_2000765Biological processregulation of cytoplasmic translation
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001649Biological processosteoblast differentiation
GO_0050684Biological processregulation of mRNA processing
GO_0050729Biological processpositive regulation of inflammatory response
GO_0006353Biological processDNA-templated transcription termination
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_0051028Biological processmRNA transport
GO_0045739Biological processpositive regulation of DNA repair
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0044806Biological processG-quadruplex DNA unwinding
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0050691Biological processregulation of defense response to virus by host
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0046833Biological processpositive regulation of RNA export from nucleus
GO_1903608Biological processprotein localization to cytoplasmic stress granule
GO_0070269Biological processpyroptotic inflammatory response
GO_0060760Biological processpositive regulation of response to cytokine stimulus
GO_0065003Biological processprotein-containing complex assembly
GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_0071356Biological processcellular response to tumor necrosis factor
GO_1900152Biological processnegative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0005726Cellular componentperichromatin fibrils
GO_0070937Cellular componentCRD-mediated mRNA stability complex
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0070578Cellular componentRISC-loading complex
GO_0005654Cellular componentnucleoplasm
GO_0015629Cellular componentactin cytoskeleton
GO_0016604Cellular componentnuclear body
GO_1990904Cellular componentribonucleoprotein complex
GO_0005622Cellular componentintracellular anatomical structure
GO_0016020Cellular componentmembrane
GO_0097165Cellular componentnuclear stress granule
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005829Cellular componentcytosol
GO_0016442Cellular componentRISC complex
GO_1990518Molecular functionsingle-stranded 3'-5' DNA helicase activity
GO_0043022Molecular functionribosome binding
GO_0045142Molecular functiontriplex DNA binding
GO_1905172Molecular functionRISC complex binding
GO_0005524Molecular functionATP binding
GO_0031490Molecular functionchromatin DNA binding
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0034458Molecular function3'-5' RNA helicase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003678Molecular functionDNA helicase activity
GO_0046872Molecular functionmetal ion binding
GO_0003724Molecular functionRNA helicase activity
GO_0017111Molecular functionribonucleoside triphosphate phosphatase activity
GO_0035197Molecular functionsiRNA binding
GO_0003729Molecular functionmRNA binding
GO_0033679Molecular function3'-5' DNA/RNA helicase activity
GO_0047429Molecular functionnucleoside triphosphate diphosphatase activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0043138Molecular function3'-5' DNA helicase activity
GO_0070063Molecular functionRNA polymerase binding
GO_0003677Molecular functionDNA binding
GO_1990825Molecular functionsequence-specific mRNA binding
GO_0061676Molecular functionimportin-alpha family protein binding
GO_0003688Molecular functionDNA replication origin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0001069Molecular functionregulatory region RNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0035613Molecular functionRNA stem-loop binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDHX9
Protein nameDHX9 protein
ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A)
SynonymsLKP
NDH2
DDX9
DescriptionFUNCTION: Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing . Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) . Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes . Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA . Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A . Plays a role in DNA replication at origins of replication and cell cycle progression . Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 . Binds to the CDKN2A promoter . Plays several roles in post-transcriptional regulation of gene expression . In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes . As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Acts also as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition . Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA . Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability . Plays a role in mRNA translation . Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) . Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs . Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation . Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process . Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection . This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis . Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus . .; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity . Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA . Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs . Involved also in HIV-1 mRNA splicing and transport . Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) . Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity . Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses . Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide . .

AccessionsQ58F26
ENST00000367549.4 [Q08211-1]
Q6PJK6
Q08211