GBP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051715Biological processcytolysis in another organism
GO_0140639Biological processpositive regulation of pyroptotic inflammatory response
GO_0006954Biological processinflammatory response
GO_0140973Biological processpositive regulation of AIM2 inflammasome complex assembly
GO_0051607Biological processdefense response to virus
GO_0006605Biological processprotein targeting
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0045089Biological processpositive regulation of innate immune response
GO_0034067Biological processprotein localization to Golgi apparatus
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0032741Biological processpositive regulation of interleukin-18 production
GO_0042742Biological processdefense response to bacterium
GO_0002218Biological processactivation of innate immune response
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0071346Biological processcellular response to type II interferon
GO_0051289Biological processprotein homotetramerization
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005737Cellular componentcytoplasm
GO_0106139Cellular componentsymbiont cell surface
GO_0098552Cellular componentside of membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0140678Molecular functionmolecular function inhibitor activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGBP5
Protein nameGuanylate binding protein 5
Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5)
SynonymsUNQ2427/PRO4987
DescriptionFUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP . Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents . Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins . .; FUNCTION: Antigenic tumor-specific truncated splice form. .

AccessionsENST00000443807.1
ENST00000370459.8 [Q96PP8-1]
E7ETN8
Q96PP8