IL22 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL22 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL22 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0050728Biological processnegative regulation of inflammatory response
GO_0006953Biological processacute-phase response
GO_0006954Biological processinflammatory response
GO_0051384Biological processresponse to glucocorticoid
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0045518Molecular functioninterleukin-22 receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL22
Protein nameInterleukin-22 (IL-22) (Cytokine Zcyto18) (IL-10-related T-cell-derived-inducible factor) (IL-TIF)
Interferon 2B1 (Interleukin 22)
Interleukin 22
SynonymsILTIF
IF2B1
UNQ3099/PRO10096
ZCYTO18
hCG_15986
DescriptionFUNCTION: Cytokine that plays a critical role in modulating tissue responses during inflammation . Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage . Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB . Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways . Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (By similarity). Promotes epithelial cell spreading (By similarity). .

AccessionsA0A7R8C389
Q6NZ84
ENST00000328087.6
Q6NWP4
ENST00000538666.6
Q6NZ83
Q9GZX6