IL34 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL34 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	99%	1783.41	255 / 258	90%	31.86	206 / 230
brain	72%	764.18	1911 / 2642	85%	11.12	602 / 705
thymus	56%	386.22	363 / 653	98%	18.05	591 / 605
prostate	59%	464.08	144 / 245	86%	6.80	434 / 502
breast	64%	803.29	292 / 459	79%	15.28	879 / 1118
skin	72%	3492.44	1300 / 1809	62%	10.50	294 / 472
kidney	37%	290.70	33 / 89	83%	11.88	749 / 901
lung	48%	332.45	275 / 578	70%	7.10	810 / 1155
esophagus	60%	862.06	862 / 1445	56%	4.84	102 / 183
intestine	36%	275.73	347 / 966	71%	6.54	375 / 527
uterus	34%	257.47	57 / 170	69%	10.96	319 / 459
lymph node	0%	0	0 / 0	100%	12.89	29 / 29
spleen	100%	8920.39	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	7.73	1 / 1
pancreas	1%	6.29	4 / 328	90%	9.29	161 / 178
stomach	11%	76.09	40 / 359	78%	7.76	222 / 286
tonsil	0%	0	0 / 0	84%	15.48	38 / 45
bladder	24%	237.76	5 / 21	59%	6.07	298 / 504
ovary	3%	22.94	6 / 180	70%	7.40	302 / 430
blood vessel	73%	1114.32	969 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	63%	4.25	50 / 80
liver	3%	14.69	6 / 226	58%	6.79	236 / 406
adipose	36%	285.37	437 / 1204	0%	0	0 / 0
muscle	30%	340.16	239 / 803	0%	0	0 / 0
heart	10%	56.75	89 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0120041	Biological process	positive regulation of macrophage proliferation
GO_0006954	Biological process	inflammatory response
GO_0045651	Biological process	positive regulation of macrophage differentiation
GO_0061518	Biological process	microglial cell proliferation
GO_0061514	Biological process	interleukin-34-mediated signaling pathway
GO_0045087	Biological process	innate immune response
GO_0010628	Biological process	positive regulation of gene expression
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0045657	Biological process	positive regulation of monocyte differentiation
GO_0010759	Biological process	positive regulation of macrophage chemotaxis
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0048714	Biological process	positive regulation of oligodendrocyte differentiation
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0061098	Biological process	positive regulation of protein tyrosine kinase activity
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005157	Molecular function	macrophage colony-stimulating factor receptor binding
GO_0008083	Molecular function	growth factor activity
GO_0005125	Molecular function	cytokine activity
GO_0005515	Molecular function	protein binding

Gene name	IL34
Protein name	Interleukin-34 (IL-34) Interleukin 34
Synonyms	C16orf77
Description	FUNCTION: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. .
Accessions	ENST00000429149.6 [Q6ZMJ4-1] ENST00000288098.7 [Q6ZMJ4-1] J3QQT3 ENST00000566361.1 Q6ZMJ4

IL34 report