IL10RB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006955Biological processimmune response
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0098586Biological processcellular response to virus
GO_0051607Biological processdefense response to virus
GO_0006954Biological processinflammatory response
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0038196Biological processtype III interferon-mediated signaling pathway
GO_1901857Biological processpositive regulation of cellular respiration
GO_0140105Biological processinterleukin-10-mediated signaling pathway
GO_0032002Cellular componentinterleukin-28 receptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0015026Molecular functioncoreceptor activity
GO_0038023Molecular functionsignaling receptor activity
GO_0004920Molecular functioninterleukin-10 receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIL10RB
Protein nameInterleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
Interleukin 10 receptor subunit beta
Interleukin 10 beta receptor
SynonymsD21S66
CRFB4
D21S58
DescriptionFUNCTION: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. .

AccessionsH7C0Z5
Q08334
A0A1B0GTI5
H2DF06
A0A1B0GU52
ENST00000422891.5
ENST00000609556.3
ENST00000637650.2
ENST00000290200.7
ENST00000451065.1
F8WDX2