Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| classical monocyte | 12 studies | 22% ± 6% | |
| non-classical monocyte | 10 studies | 24% ± 5% | |
| macrophage | 10 studies | 26% ± 7% | |
| monocyte | 8 studies | 20% ± 6% | |
| endothelial cell | 6 studies | 22% ± 6% | |
| plasmacytoid dendritic cell | 5 studies | 23% ± 6% | |
| epithelial cell | 4 studies | 29% ± 14% | |
| myeloid cell | 4 studies | 24% ± 11% | |
| type I pneumocyte | 4 studies | 18% ± 2% | |
| goblet cell | 4 studies | 24% ± 3% | |
| placental villous trophoblast | 3 studies | 37% ± 9% | |
| fibroblast | 3 studies | 25% ± 6% | |
| conventional dendritic cell | 3 studies | 23% ± 6% | |
| microglial cell | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 1354.82 | 89 / 89 | 30% | 0.41 | 266 / 901 |
| bladder | 100% | 1682.52 | 21 / 21 | 27% | 0.40 | 137 / 504 |
| pancreas | 99% | 1376.13 | 326 / 328 | 26% | 0.38 | 47 / 178 |
| intestine | 100% | 2343.45 | 966 / 966 | 23% | 0.34 | 119 / 527 |
| brain | 92% | 627.26 | 2421 / 2642 | 31% | 0.46 | 218 / 705 |
| stomach | 100% | 1781.69 | 359 / 359 | 21% | 0.32 | 61 / 286 |
| esophagus | 100% | 1728.12 | 1444 / 1445 | 21% | 0.28 | 39 / 183 |
| ovary | 100% | 1743.94 | 180 / 180 | 20% | 0.27 | 85 / 430 |
| lung | 100% | 2627.50 | 578 / 578 | 18% | 0.26 | 208 / 1155 |
| thymus | 100% | 1491.11 | 653 / 653 | 9% | 0.15 | 54 / 605 |
| uterus | 100% | 1635.51 | 170 / 170 | 8% | 0.11 | 35 / 459 |
| breast | 100% | 1866.20 | 459 / 459 | 7% | 0.09 | 73 / 1118 |
| liver | 100% | 1410.00 | 226 / 226 | 5% | 0.07 | 20 / 406 |
| prostate | 100% | 1756.96 | 245 / 245 | 4% | 0.05 | 18 / 502 |
| skin | 100% | 2190.47 | 1808 / 1809 | 3% | 0.03 | 12 / 472 |
| adrenal gland | 100% | 1389.90 | 258 / 258 | 2% | 0.02 | 4 / 230 |
| adipose | 100% | 2306.89 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 7834.09 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4573.81 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1377.91 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 851.62 | 838 / 861 | 0% | 0 | 0 / 0 |
| muscle | 93% | 726.36 | 746 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 34% | 0.43 | 10 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0006955 | Biological process | immune response |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0098586 | Biological process | cellular response to virus |
| GO_0051607 | Biological process | defense response to virus |
| GO_0006954 | Biological process | inflammatory response |
| GO_0046427 | Biological process | positive regulation of receptor signaling pathway via JAK-STAT |
| GO_0038196 | Biological process | type III interferon-mediated signaling pathway |
| GO_1901857 | Biological process | positive regulation of cellular respiration |
| GO_0140105 | Biological process | interleukin-10-mediated signaling pathway |
| GO_0032002 | Cellular component | interleukin-28 receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0015026 | Molecular function | coreceptor activity |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0004920 | Molecular function | interleukin-10 receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IL10RB |
| Protein name | Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b) Interleukin 10 receptor subunit beta Interleukin 10 beta receptor |
| Synonyms | D21S66 CRFB4 D21S58 |
| Description | FUNCTION: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. . |
| Accessions | H7C0Z5 Q08334 A0A1B0GTI5 H2DF06 A0A1B0GU52 ENST00000422891.5 ENST00000609556.3 ENST00000637650.2 ENST00000290200.7 ENST00000451065.1 F8WDX2 |