Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| kidney loop of Henle epithelial cell | 8 studies | 51% ± 18% | |
| kidney distal convoluted tubule epithelial cell | 5 studies | 77% ± 23% | |
| hepatocyte | 5 studies | 82% ± 10% | |
| endothelial cell | 3 studies | 31% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 47978.21 | 226 / 226 | 97% | 775.84 | 394 / 406 |
| kidney | 100% | 9095.82 | 89 / 89 | 15% | 6.68 | 139 / 901 |
| heart | 76% | 12.48 | 652 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 65% | 5.67 | 212 / 328 | 9% | 0.14 | 16 / 178 |
| intestine | 53% | 17.01 | 516 / 966 | 9% | 0.98 | 49 / 527 |
| spleen | 54% | 65.08 | 130 / 241 | 0% | 0 | 0 / 0 |
| lung | 49% | 4.61 | 283 / 578 | 3% | 0.25 | 40 / 1155 |
| peripheral blood | 52% | 45.57 | 483 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 47% | 4.56 | 121 / 258 | 3% | 0.15 | 6 / 230 |
| stomach | 38% | 2.71 | 135 / 359 | 9% | 0.18 | 25 / 286 |
| prostate | 42% | 2.99 | 104 / 245 | 2% | 0.04 | 10 / 502 |
| uterus | 41% | 4.19 | 69 / 170 | 2% | 0.05 | 11 / 459 |
| brain | 42% | 7.08 | 1111 / 2642 | 0% | 0.00 | 1 / 705 |
| thymus | 40% | 3.49 | 261 / 653 | 0% | 0.01 | 2 / 605 |
| esophagus | 36% | 3.50 | 516 / 1445 | 4% | 0.39 | 7 / 183 |
| bladder | 33% | 1.90 | 7 / 21 | 4% | 0.10 | 22 / 504 |
| ovary | 36% | 2.73 | 65 / 180 | 0% | 0 | 0 / 430 |
| skin | 35% | 3.54 | 625 / 1809 | 1% | 0.04 | 6 / 472 |
| adipose | 34% | 9.42 | 412 / 1204 | 0% | 0 | 0 / 0 |
| breast | 28% | 5.58 | 127 / 459 | 1% | 0.05 | 6 / 1118 |
| blood vessel | 25% | 2.60 | 334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 18% | 1.33 | 147 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.05 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006954 | Biological process | inflammatory response |
| GO_0010951 | Biological process | negative regulation of endopeptidase activity |
| GO_0007165 | Biological process | signal transduction |
| GO_0007162 | Biological process | negative regulation of cell adhesion |
| GO_0007596 | Biological process | blood coagulation |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0045861 | Biological process | negative regulation of proteolysis |
| GO_0030195 | Biological process | negative regulation of blood coagulation |
| GO_0042311 | Biological process | vasodilation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0072562 | Cellular component | blood microparticle |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0004869 | Molecular function | cysteine-type endopeptidase inhibitor activity |
| GO_0008201 | Molecular function | heparin binding |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KNG1 |
| Protein name | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] KNG1 protein Kininogen 1, isoform CRA_b (cDNA FLJ56836, highly similar to Kininogen-1) |
| Synonyms | KNG BDK hCG_2021397 |
| Description | FUNCTION: Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). . |
| Accessions | B4E1C2 ENST00000287611.8 [P01042-2] P01042 Q05CF8 ENST00000644859.2 [P01042-1] ENST00000447445.1 [P01042-3] |
