RELA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0006954Biological processinflammatory response
GO_0032495Biological processresponse to muramyl dipeptide
GO_0014040Biological processpositive regulation of Schwann cell differentiation
GO_0038084Biological processvascular endothelial growth factor signaling pathway
GO_0010224Biological processresponse to UV-B
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0033590Biological processresponse to cobalamin
GO_0051591Biological processresponse to cAMP
GO_0043066Biological processnegative regulation of apoptotic process
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0030163Biological processprotein catabolic process
GO_0002357Biological processdefense response to tumor cell
GO_0038161Biological processprolactin signaling pathway
GO_1904996Biological processpositive regulation of leukocyte adhesion to vascular endothelial cell
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0071354Biological processcellular response to interleukin-6
GO_1904385Biological processcellular response to angiotensin
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0043200Biological processresponse to amino acid
GO_0002931Biological processresponse to ischemia
GO_0140374Biological processantiviral innate immune response
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0010628Biological processpositive regulation of gene expression
GO_0071347Biological processcellular response to interleukin-1
GO_0050727Biological processregulation of inflammatory response
GO_0006351Biological processDNA-templated transcription
GO_0071223Biological processcellular response to lipoteichoic acid
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0006355Biological processregulation of DNA-templated transcription
GO_0099527Biological processpostsynapse to nucleus signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0070431Biological processnucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0033554Biological processcellular response to stress
GO_0009887Biological processanimal organ morphogenesis
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0071224Biological processcellular response to peptidoglycan
GO_0001889Biological processliver development
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032570Biological processresponse to progesterone
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006325Biological processchromatin organization
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0035994Biological processresponse to muscle stretch
GO_0007218Biological processneuropeptide signaling pathway
GO_0034097Biological processresponse to cytokine
GO_0035729Biological processcellular response to hepatocyte growth factor stimulus
GO_0051607Biological processdefense response to virus
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0006117Biological processacetaldehyde metabolic process
GO_0032868Biological processresponse to insulin
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_2000630Biological processpositive regulation of miRNA metabolic process
GO_0070555Biological processresponse to interleukin-1
GO_0006968Biological processcellular defense response
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0016525Biological processnegative regulation of angiogenesis
GO_0033234Biological processnegative regulation of protein sumoylation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0035556Biological processintracellular signal transduction
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0001942Biological processhair follicle development
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0071316Biological processcellular response to nicotine
GO_0098978Cellular componentglutamatergic synapse
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0035525Cellular componentNF-kappaB p50/p65 complex
GO_0071159Cellular componentNF-kappaB complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005829Cellular componentcytosol
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0071532Molecular functionankyrin repeat binding
GO_0031490Molecular functionchromatin DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0140296Molecular functiongeneral transcription initiation factor binding
GO_0000979Molecular functionRNA polymerase II core promoter sequence-specific DNA binding
GO_0042826Molecular functionhistone deacetylase binding
GO_0019899Molecular functionenzyme binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0042277Molecular functionpeptide binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0042301Molecular functionphosphate ion binding
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0019901Molecular functionprotein kinase binding
GO_0042805Molecular functionactinin binding
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameRELA
Protein nameRELA protein (RELA proto-oncogene, NF-kB subunit)
RELA protein
RELA proto-oncogene, NF-kB subunit
Alternative protein RELA
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
SynonymsNFKB3
DescriptionFUNCTION: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells . The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection . .

AccessionsENST00000525693.5
ENST00000529389.5
E9PMD5
E9PI38
ENST00000531238.1
ENST00000534558.5
E9PKV4
ENST00000534283.1
ENST00000532879.5
E9PNK5
A0A087X0W8
ENST00000308639.13 [Q04206-4]
ENST00000533187.5
L0R6N5
E9PJR1
ENST00000525658.5
E9PJZ9
Q2TAM5
Q96CP1
E9PM47
ENST00000533546.5
E9PQS6
ENST00000526257.1
E9PNV4
ENST00000527874.1
E9PSE4
Q04206
ENST00000532999.5
ENST00000527749.5
E9PKH5
ENST00000612991.4
ENST00000406246.8 [Q04206-1]
Q96F54
ENST00000526283.6
E9PRX2
H0YCB4