IKBKG report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IKBKG at tissue level.

III. Associated gene sets

GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0009615Biological processresponse to virus
GO_0006974Biological processDNA damage response
GO_0043276Biological processanoikis
GO_0050852Biological processT cell receptor signaling pathway
GO_0065003Biological processprotein-containing complex assembly
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0006955Biological processimmune response
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0016239Biological processpositive regulation of macroautophagy
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042742Biological processdefense response to bacterium
GO_0006915Biological processapoptotic process
GO_0051650Biological processestablishment of vesicle localization
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000151Cellular componentubiquitin ligase complex
GO_0000922Cellular componentspindle pole
GO_0072686Cellular componentmitotic spindle
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008385Cellular componentIkappaB kinase complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_1990459Molecular functiontransferrin receptor binding
GO_0019904Molecular functionprotein domain specific binding
GO_1990450Molecular functionlinear polyubiquitin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0046872Molecular functionmetal ion binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIKBKG
Protein nameNF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b (Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma)
NF-kappa-B essential modulator (IkB kinase-associated protein 1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (NF-kappa-B essential modifier)
NF-kappa-B essential modulator
SynonymsFIP3
NEMO
hCG_2003089
DescriptionFUNCTION: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor . Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways . Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin . Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 . Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination . .; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. .

AccessionsC9JN51
ENST00000689906.1
A0A087WUW6
ENST00000692948.1
ENST00000445622
A0A8I5KQX5
ENST00000422680
ENST00000594239.6 [Q9Y6K9-1]
ENST00000440286
ENST00000619941.4
A0A087X1K7
C9JCG6
A0A087WWQ9
ENST00000445622.6 [Q9Y6K9-1]
ENST00000615874.4
ENST00000611176.4 [Q9Y6K9-3]
ENST00000612051.1
ENST00000618670.4 [Q9Y6K9-2]
A0A087X1B1
ENST00000492469.3
Q9Y6K9
C9JH59
ENST00000686774.1
ENST00000440286.6 [Q9Y6K9-1]
A0A8I5KQX1
ENST00000422680.6 [Q9Y6K9-1]
A0A8I5KRU9
A0A087X0G7
ENST00000686378.1
A0A8I5KYQ7
ENST00000615186.5
C9J2V2
ENST00000617207.4
ENST00000611071.4 [Q9Y6K9-1]
D3DWY0
ENST00000413620.6