HK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046835Biological processcarbohydrate phosphorylation
GO_0006954Biological processinflammatory response
GO_0006096Biological processglycolytic process
GO_0045087Biological processinnate immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0006002Biological processfructose 6-phosphate metabolic process
GO_0001678Biological processintracellular glucose homeostasis
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0061621Biological processcanonical glycolysis
GO_0072656Biological processmaintenance of protein location in mitochondrion
GO_0072655Biological processestablishment of protein localization to mitochondrion
GO_0006013Biological processmannose metabolic process
GO_0051156Biological processglucose 6-phosphate metabolic process
GO_0006006Biological processglucose metabolic process
GO_0045121Cellular componentmembrane raft
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005741Cellular componentmitochondrial outer membrane
GO_0047931Molecular functionglucosamine kinase activity
GO_0004396Molecular functionhexokinase activity
GO_0042834Molecular functionpeptidoglycan binding
GO_0019158Molecular functionmannokinase activity
GO_0005524Molecular functionATP binding
GO_0008865Molecular functionfructokinase activity
GO_0005536Molecular functionD-glucose binding
GO_0005515Molecular functionprotein binding
GO_0004340Molecular functionglucokinase activity

IV. Literature review

[source]
Gene nameHK1
Protein nameHexokinase-1 (EC 2.7.1.1) (Hexokinase type I)
Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A)
Hexokinase 1 (EC 2.7.1.1)
Hexokinase 1
Phosphotransferase (EC 2.7.1.-)
SynonymsHK1-ta
HK1-tb
DescriptionFUNCTION: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) . Does not phosphorylate N-acetyl-D-glucosamine . Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan . When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome . .

AccessionsA0A994J432
ENST00000703948.1
ENST00000703947.1
P78542
ENST00000298649.8 [P19367-2]
P19367
ENST00000483077.5
ENST00000421088.5
ENST00000436817.6 [P19367-3]
A0A2R8YEE7
A0A994J6R6
ENST00000450646.6
A0A994J4Q0
ENST00000703953.1
A0A994J6Q7
ENST00000703946.1
A0A994J4Q4
A0A994J6R1
A0A994J758
ENST00000359426.7 [P19367-1]
B1AR62
A0A994J495
A0A2R8Y7T9
A0A994J4A4
ENST00000703950.1
ENST00000470050.2
A0A2R8Y626
A0A994J761
ENST00000703944.1
ENST00000483054.5
ENST00000703954.1
ENST00000703945.1
ENST00000643399.2 [P19367-3]
ENST00000703952.1
A0A994J499
ENST00000493591.6
ENST00000703949.1
ENST00000476368.6
A0A994J4P6
ENST00000464803.6
A0A994J428
ENST00000703951.1
A0A994J753