Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 16 studies | 28% ± 10% | |
| non-classical monocyte | 14 studies | 27% ± 12% | |
| classical monocyte | 12 studies | 24% ± 10% | |
| glutamatergic neuron | 11 studies | 37% ± 23% | |
| ciliated cell | 10 studies | 23% ± 8% | |
| monocyte | 10 studies | 22% ± 5% | |
| astrocyte | 10 studies | 32% ± 11% | |
| microglial cell | 9 studies | 27% ± 11% | |
| basal cell | 8 studies | 30% ± 17% | |
| GABAergic neuron | 8 studies | 38% ± 20% | |
| myeloid cell | 8 studies | 24% ± 5% | |
| macrophage | 8 studies | 26% ± 9% | |
| fibroblast | 7 studies | 23% ± 4% | |
| smooth muscle cell | 6 studies | 18% ± 3% | |
| platelet | 6 studies | 25% ± 8% | |
| epithelial cell | 6 studies | 37% ± 19% | |
| retina horizontal cell | 6 studies | 59% ± 19% | |
| retinal cone cell | 6 studies | 34% ± 11% | |
| retinal rod cell | 6 studies | 32% ± 7% | |
| erythrocyte | 6 studies | 31% ± 17% | |
| neuron | 5 studies | 30% ± 7% | |
| retinal ganglion cell | 5 studies | 60% ± 23% | |
| cardiac muscle cell | 5 studies | 23% ± 3% | |
| type I pneumocyte | 5 studies | 19% ± 3% | |
| type II pneumocyte | 5 studies | 21% ± 4% | |
| club cell | 5 studies | 20% ± 5% | |
| pericyte | 5 studies | 19% ± 2% | |
| regulatory T cell | 5 studies | 18% ± 1% | |
| secretory cell | 4 studies | 19% ± 2% | |
| CD4-positive, alpha-beta T cell | 4 studies | 20% ± 2% | |
| retinal bipolar neuron | 4 studies | 22% ± 5% | |
| OFF-bipolar cell | 4 studies | 30% ± 11% | |
| megakaryocyte | 4 studies | 30% ± 9% | |
| amacrine cell | 4 studies | 33% ± 10% | |
| retinal pigment epithelial cell | 4 studies | 26% ± 8% | |
| adipocyte | 4 studies | 21% ± 2% | |
| dendritic cell | 4 studies | 28% ± 12% | |
| mononuclear phagocyte | 4 studies | 22% ± 6% | |
| lymphocyte | 4 studies | 21% ± 3% | |
| erythroblast | 4 studies | 36% ± 23% | |
| CD8-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
| effector memory CD4-positive, alpha-beta T cell | 4 studies | 16% ± 2% | |
| T cell | 4 studies | 17% ± 1% | |
| interneuron | 4 studies | 44% ± 20% | |
| conventional dendritic cell | 3 studies | 35% ± 13% | |
| GABAergic interneuron | 3 studies | 20% ± 4% | |
| Mueller cell | 3 studies | 42% ± 5% | |
| ON-bipolar cell | 3 studies | 34% ± 14% | |
| rod bipolar cell | 3 studies | 24% ± 2% | |
| intermediate monocyte | 3 studies | 32% ± 14% | |
| endothelial cell of lymphatic vessel | 3 studies | 24% ± 10% | |
| alveolar macrophage | 3 studies | 32% ± 10% | |
| goblet cell | 3 studies | 43% ± 18% | |
| granule cell | 3 studies | 24% ± 5% | |
| natural killer cell | 3 studies | 18% ± 3% | |
| CD4-positive, alpha-beta memory T cell | 3 studies | 20% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 9904.73 | 245 / 245 | 100% | 97.86 | 502 / 502 |
| breast | 100% | 7615.87 | 459 / 459 | 100% | 125.87 | 1116 / 1118 |
| thymus | 100% | 12349.22 | 652 / 653 | 100% | 83.50 | 604 / 605 |
| esophagus | 100% | 15906.98 | 1445 / 1445 | 99% | 93.80 | 182 / 183 |
| uterus | 99% | 6676.47 | 169 / 170 | 100% | 97.89 | 459 / 459 |
| skin | 100% | 16185.81 | 1808 / 1809 | 99% | 102.06 | 469 / 472 |
| bladder | 100% | 13097.48 | 21 / 21 | 99% | 92.02 | 499 / 504 |
| lung | 99% | 8891.77 | 574 / 578 | 99% | 99.10 | 1142 / 1155 |
| intestine | 99% | 8443.93 | 954 / 966 | 98% | 62.17 | 519 / 527 |
| stomach | 98% | 8822.96 | 353 / 359 | 98% | 52.16 | 279 / 286 |
| brain | 96% | 11582.67 | 2535 / 2642 | 100% | 75.49 | 703 / 705 |
| kidney | 91% | 4995.30 | 81 / 89 | 93% | 60.19 | 836 / 901 |
| adrenal gland | 90% | 3987.73 | 231 / 258 | 92% | 72.82 | 212 / 230 |
| ovary | 77% | 3031.12 | 139 / 180 | 98% | 44.71 | 421 / 430 |
| pancreas | 12% | 367.53 | 40 / 328 | 97% | 73.04 | 172 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 79.07 | 29 / 29 |
| muscle | 100% | 19533.33 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 7067.44 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 114.32 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 49.75 | 1 / 1 |
| adipose | 100% | 7673.12 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 13515.54 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 8555.77 | 921 / 929 | 0% | 0 | 0 / 0 |
| heart | 97% | 17149.59 | 831 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 84.08 | 77 / 80 |
| liver | 3% | 114.10 | 6 / 226 | 18% | 8.30 | 73 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0046835 | Biological process | carbohydrate phosphorylation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0006096 | Biological process | glycolytic process |
| GO_0045087 | Biological process | innate immune response |
| GO_0002720 | Biological process | positive regulation of cytokine production involved in immune response |
| GO_0006002 | Biological process | fructose 6-phosphate metabolic process |
| GO_0001678 | Biological process | intracellular glucose homeostasis |
| GO_0032731 | Biological process | positive regulation of interleukin-1 beta production |
| GO_0061621 | Biological process | canonical glycolysis |
| GO_0072656 | Biological process | maintenance of protein location in mitochondrion |
| GO_0072655 | Biological process | establishment of protein localization to mitochondrion |
| GO_0006013 | Biological process | mannose metabolic process |
| GO_0051156 | Biological process | glucose 6-phosphate metabolic process |
| GO_0006006 | Biological process | glucose metabolic process |
| GO_0045121 | Cellular component | membrane raft |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_0047931 | Molecular function | glucosamine kinase activity |
| GO_0004396 | Molecular function | hexokinase activity |
| GO_0042834 | Molecular function | peptidoglycan binding |
| GO_0019158 | Molecular function | mannokinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0008865 | Molecular function | fructokinase activity |
| GO_0005536 | Molecular function | D-glucose binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004340 | Molecular function | glucokinase activity |
| Gene name | HK1 |
| Protein name | Hexokinase-1 (EC 2.7.1.1) (Hexokinase type I) Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) Hexokinase 1 (EC 2.7.1.1) Hexokinase 1 Phosphotransferase (EC 2.7.1.-) |
| Synonyms | HK1-ta HK1-tb |
| Description | FUNCTION: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) . Does not phosphorylate N-acetyl-D-glucosamine . Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan . When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome . . |
| Accessions | A0A994J432 ENST00000703948.1 ENST00000703947.1 P78542 ENST00000298649.8 [P19367-2] P19367 ENST00000483077.5 ENST00000421088.5 ENST00000436817.6 [P19367-3] A0A2R8YEE7 A0A994J6R6 ENST00000450646.6 A0A994J4Q0 ENST00000703953.1 A0A994J6Q7 ENST00000703946.1 A0A994J4Q4 A0A994J6R1 A0A994J758 ENST00000359426.7 [P19367-1] B1AR62 A0A994J495 A0A2R8Y7T9 A0A994J4A4 ENST00000703950.1 ENST00000470050.2 A0A2R8Y626 A0A994J761 ENST00000703944.1 ENST00000483054.5 ENST00000703954.1 ENST00000703945.1 ENST00000643399.2 [P19367-3] ENST00000703952.1 A0A994J499 ENST00000493591.6 ENST00000703949.1 ENST00000476368.6 A0A994J4P6 ENST00000464803.6 A0A994J428 ENST00000703951.1 A0A994J753 |