S100A12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050832Biological processdefense response to fungus
GO_0006954Biological processinflammatory response
GO_0006805Biological processxenobiotic metabolic process
GO_0045087Biological processinnate immune response
GO_0030593Biological processneutrophil chemotaxis
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0031640Biological processkilling of cells of another organism
GO_0043542Biological processendothelial cell migration
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042742Biological processdefense response to bacterium
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0050729Biological processpositive regulation of inflammatory response
GO_0002548Biological processmonocyte chemotaxis
GO_0045576Biological processmast cell activation
GO_0005856Cellular componentcytoskeleton
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0034774Cellular componentsecretory granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0008270Molecular functionzinc ion binding
GO_0050786Molecular functionRAGE receptor binding
GO_0005507Molecular functioncopper ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameS100A12
Protein nameProtein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
Synonyms
DescriptionFUNCTION: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. .

AccessionsENST00000368737.5
P80511