CD2AP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	27 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	18 studies	47% ± 14%	Explore
epithelial cell	12 studies	38% ± 19%	Explore
ciliated cell	12 studies	28% ± 12%	Explore
microglial cell	10 studies	29% ± 10%	Explore
type I pneumocyte	9 studies	29% ± 11%	Explore
macrophage	9 studies	29% ± 12%	Explore
basal cell	8 studies	30% ± 13%	Explore
goblet cell	7 studies	32% ± 23%	Explore
secretory cell	7 studies	21% ± 6%	Explore
club cell	6 studies	34% ± 10%	Explore
type II pneumocyte	6 studies	28% ± 8%	Explore
fibroblast	6 studies	21% ± 6%	Explore
ionocyte	5 studies	31% ± 11%	Explore
glutamatergic neuron	5 studies	43% ± 19%	Explore
podocyte	5 studies	34% ± 9%	Explore
enterocyte	5 studies	23% ± 6%	Explore
capillary endothelial cell	5 studies	23% ± 7%	Explore
respiratory goblet cell	5 studies	35% ± 12%	Explore
endothelial cell of lymphatic vessel	5 studies	28% ± 8%	Explore
astrocyte	5 studies	32% ± 15%	Explore
pericyte	5 studies	21% ± 5%	Explore
neuron	4 studies	33% ± 20%	Explore
naive B cell	4 studies	17% ± 1%	Explore
dendritic cell	4 studies	27% ± 8%	Explore
T cell	4 studies	20% ± 3%	Explore
interneuron	4 studies	39% ± 22%	Explore
renal principal cell	4 studies	36% ± 7%	Explore
B cell	3 studies	23% ± 7%	Explore
mucosal invariant T cell	3 studies	17% ± 0%	Explore
squamous epithelial cell	3 studies	37% ± 25%	Explore
endothelial cell of artery	3 studies	22% ± 2%	Explore
vein endothelial cell	3 studies	37% ± 21%	Explore
lymphocyte	3 studies	26% ± 5%	Explore
myeloid cell	3 studies	21% ± 6%	Explore
endothelial cell of vascular tree	3 studies	36% ± 19%	Explore
hepatocyte	3 studies	39% ± 24%	Explore
GABAergic neuron	3 studies	50% ± 4%	Explore
enteroendocrine cell	3 studies	22% ± 4%	Explore
smooth muscle cell	3 studies	18% ± 1%	Explore
oligodendrocyte	3 studies	25% ± 13%	Explore
epithelial cell of proximal tubule	3 studies	20% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	26% ± 8%	Explore
mucus secreting cell	3 studies	33% ± 4%	Explore
kidney loop of Henle epithelial cell	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	24% ± 7%	Explore
brain	6 studies	35% ± 15%	Explore
kidney	4 studies	24% ± 7%	Explore
liver	3 studies	33% ± 13%	Explore
intestine	3 studies	18% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2431.12	1445 / 1445	100%	71.56	183 / 183
prostate	100%	2601.49	245 / 245	100%	54.41	502 / 502
lung	100%	2762.28	578 / 578	100%	52.86	1154 / 1155
breast	100%	2637.19	459 / 459	99%	53.47	1110 / 1118
pancreas	100%	2285.84	328 / 328	99%	53.97	176 / 178
bladder	100%	2390.05	21 / 21	99%	53.38	497 / 504
ovary	100%	1221.74	180 / 180	98%	28.60	423 / 430
thymus	100%	2315.19	653 / 653	98%	31.21	595 / 605
kidney	100%	4311.33	89 / 89	98%	43.13	886 / 901
stomach	100%	2616.23	359 / 359	98%	60.14	280 / 286
intestine	100%	3576.83	966 / 966	97%	58.03	511 / 527
uterus	100%	1735.32	170 / 170	96%	38.94	442 / 459
liver	100%	1665.66	226 / 226	89%	21.69	363 / 406
skin	100%	2596.03	1808 / 1809	86%	23.33	408 / 472
adrenal gland	100%	1879.75	258 / 258	84%	14.27	194 / 230
brain	93%	927.26	2445 / 2642	38%	4.35	269 / 705
adipose	100%	2586.15	1204 / 1204	0%	0	0 / 0
spleen	100%	1642.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	31.45	45 / 45
ureter	0%	0	0 / 0	100%	16.71	1 / 1
blood vessel	100%	1724.93	1334 / 1335	0%	0	0 / 0
muscle	99%	1071.17	795 / 803	0%	0	0 / 0
heart	99%	993.49	850 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	24.31	28 / 29
eye	0%	0	0 / 0	49%	9.40	39 / 80
peripheral blood	43%	1577.62	397 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006954	Biological process	inflammatory response
GO_0008283	Biological process	cell population proliferation
GO_0030041	Biological process	actin filament polymerization
GO_0051301	Biological process	cell division
GO_0071559	Biological process	response to transforming growth factor beta
GO_0038180	Biological process	nerve growth factor signaling pathway
GO_0051291	Biological process	protein heterooligomerization
GO_0030163	Biological process	protein catabolic process
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0046847	Biological process	filopodium assembly
GO_0006979	Biological process	response to oxidative stress
GO_0048668	Biological process	collateral sprouting
GO_0048535	Biological process	lymph node development
GO_0048011	Biological process	neurotrophin TRK receptor signaling pathway
GO_0007165	Biological process	signal transduction
GO_0032482	Biological process	Rab protein signal transduction
GO_0032911	Biological process	negative regulation of transforming growth factor beta1 production
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0045216	Biological process	cell-cell junction organization
GO_0051403	Biological process	stress-activated MAPK cascade
GO_0070371	Biological process	ERK1 and ERK2 cascade
GO_0006629	Biological process	lipid metabolic process
GO_0051058	Biological process	negative regulation of small GTPase mediated signal transduction
GO_0001771	Biological process	immunological synapse formation
GO_0032905	Biological process	transforming growth factor beta1 production
GO_0001889	Biological process	liver development
GO_0044331	Biological process	cell-cell adhesion mediated by cadherin
GO_0050714	Biological process	positive regulation of protein secretion
GO_0006930	Biological process	substrate-dependent cell migration, cell extension
GO_0003158	Biological process	endothelium development
GO_0060612	Biological process	adipose tissue development
GO_0008584	Biological process	male gonad development
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0050808	Biological process	synapse organization
GO_0009611	Biological process	response to wounding
GO_0016477	Biological process	cell migration
GO_1990790	Biological process	response to glial cell derived neurotrophic factor
GO_0072112	Biological process	podocyte differentiation
GO_0009615	Biological process	response to virus
GO_0032868	Biological process	response to insulin
GO_0061024	Biological process	membrane organization
GO_0051674	Biological process	localization of cell
GO_0065003	Biological process	protein-containing complex assembly
GO_0097018	Biological process	renal albumin absorption
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0007015	Biological process	actin filament organization
GO_0035633	Biological process	maintenance of blood-brain barrier
GO_0006915	Biological process	apoptotic process
GO_0046323	Biological process	glucose import
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_1900182	Biological process	positive regulation of protein localization to nucleus
GO_0009306	Biological process	protein secretion
GO_0034451	Cellular component	centriolar satellite
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0001726	Cellular component	ruffle
GO_0036057	Cellular component	slit diaphragm
GO_0031941	Cellular component	filamentous actin
GO_0070062	Cellular component	extracellular exosome
GO_0001650	Cellular component	fibrillar center
GO_0030425	Cellular component	dendrite
GO_0015629	Cellular component	actin cytoskeleton
GO_0005770	Cellular component	late endosome
GO_0005886	Cellular component	plasma membrane
GO_0005641	Cellular component	nuclear envelope lumen
GO_0002102	Cellular component	podosome
GO_0031252	Cellular component	cell leading edge
GO_0005737	Cellular component	cytoplasm
GO_0030424	Cellular component	axon
GO_0031594	Cellular component	neuromuscular junction
GO_0030426	Cellular component	growth cone
GO_0031982	Cellular component	vesicle
GO_0042802	Molecular function	identical protein binding
GO_0030276	Molecular function	clathrin binding
GO_0017124	Molecular function	SH3 domain binding
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding
GO_0045296	Molecular function	cadherin binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0036312	Molecular function	phosphatidylinositol 3-kinase regulatory subunit binding

Gene name	CD2AP
Protein name	CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Synonyms
Description	FUNCTION: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton . In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis . Plays a role in epithelial cell junctions formation . .
Accessions	Q9Y5K6 ENST00000359314.5

CD2AP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review