ZC3H12A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903936Biological processcellular response to sodium arsenite
GO_0010468Biological processregulation of gene expression
GO_0006954Biological processinflammatory response
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_1904637Biological processcellular response to ionomycin
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0032689Biological processnegative regulation of type II interferon production
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0010884Biological processpositive regulation of lipid storage
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0002757Biological processimmune response-activating signaling pathway
GO_0061014Biological processpositive regulation of mRNA catabolic process
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0001525Biological processangiogenesis
GO_0043031Biological processnegative regulation of macrophage activation
GO_0010629Biological processnegative regulation of gene expression
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0045766Biological processpositive regulation of angiogenesis
GO_0010628Biological processpositive regulation of gene expression
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0071347Biological processcellular response to interleukin-1
GO_0050852Biological processT cell receptor signaling pathway
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0055118Biological processnegative regulation of cardiac muscle contraction
GO_1903003Biological processpositive regulation of protein deubiquitination
GO_0010508Biological processpositive regulation of autophagy
GO_0016579Biological processprotein deubiquitination
GO_0071222Biological processcellular response to lipopolysaccharide
GO_1990869Biological processcellular response to chemokine
GO_0007399Biological processnervous system development
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0042149Biological processcellular response to glucose starvation
GO_0044828Biological processnegative regulation by host of viral genome replication
GO_0010587Biological processmiRNA catabolic process
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0034599Biological processcellular response to oxidative stress
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0051607Biological processdefense response to virus
GO_0006974Biological processDNA damage response
GO_0045019Biological processnegative regulation of nitric oxide biosynthetic process
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0098586Biological processcellular response to virus
GO_0051259Biological processprotein complex oligomerization
GO_0071356Biological processcellular response to tumor necrosis factor
GO_2000320Biological processnegative regulation of T-helper 17 cell differentiation
GO_0030154Biological processcell differentiation
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0006915Biological processapoptotic process
GO_2000627Biological processpositive regulation of miRNA catabolic process
GO_0010656Biological processnegative regulation of muscle cell apoptotic process
GO_0005856Cellular componentcytoskeleton
GO_0000932Cellular componentP-body
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0030867Cellular componentrough endoplasmic reticulum membrane
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0004532Molecular functionRNA exonuclease activity
GO_0043022Molecular functionribosome binding
GO_0004521Molecular functionRNA endonuclease activity
GO_0003682Molecular functionchromatin binding
GO_0046872Molecular functionmetal ion binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0004540Molecular functionRNA nuclease activity
GO_0003677Molecular functionDNA binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0035613Molecular functionRNA stem-loop binding

IV. Literature review

[source]
Gene nameZC3H12A
Protein nameEndoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)
Zinc finger CCCH-type containing 12A
SynonymsMCPIP1
MCPIP
DescriptionFUNCTION: Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay . Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation . Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner . Plays a role in the inhibition of microRNAs (miRNAs) biogenesis . Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs . Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity . Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes . Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage . Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis . Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway . Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). .; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. .; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. .

AccessionsENST00000640233.1
Q5D1E8
R4GN17
A0A1W2PQC8
C0LED9
ENST00000471012.1
ENST00000373087.7