IL1B | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	29 studies	37% ± 17%	Explore
classical monocyte	24 studies	44% ± 21%	Explore
monocyte	20 studies	46% ± 23%	Explore
conventional dendritic cell	20 studies	36% ± 10%	Explore
non-classical monocyte	17 studies	41% ± 21%	Explore
dendritic cell	13 studies	32% ± 17%	Explore
myeloid cell	9 studies	39% ± 20%	Explore
neutrophil	6 studies	61% ± 24%	Explore
mononuclear phagocyte	6 studies	45% ± 15%	Explore
alveolar macrophage	5 studies	24% ± 9%	Explore
leukocyte	5 studies	30% ± 6%	Explore
intermediate monocyte	4 studies	48% ± 20%	Explore
hematopoietic stem cell	4 studies	30% ± 6%	Explore
hematopoietic precursor cell	3 studies	32% ± 15%	Explore
monocyte-derived dendritic cell	3 studies	60% ± 32%	Explore
microglial cell	3 studies	39% ± 22%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	62% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	26% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	96%	1282.92	554 / 578	83%	16.25	954 / 1155
stomach	75%	1346.01	269 / 359	87%	34.61	250 / 286
intestine	47%	187.13	455 / 966	87%	30.45	461 / 527
bladder	52%	86.81	11 / 21	77%	30.52	389 / 504
esophagus	31%	94.28	451 / 1445	86%	30.27	157 / 183
kidney	52%	91.74	46 / 89	58%	5.17	519 / 901
brain	41%	160.66	1085 / 2642	67%	14.69	470 / 705
spleen	100%	1172.62	241 / 241	0%	0	0 / 0
peripheral blood	95%	2063.54	887 / 929	0%	0	0 / 0
ovary	21%	53.33	37 / 180	73%	7.92	314 / 430
tonsil	0%	0	0 / 0	93%	24.95	42 / 45
uterus	17%	30.51	29 / 170	66%	16.59	304 / 459
pancreas	23%	36.15	77 / 328	56%	7.26	99 / 178
breast	16%	25.88	72 / 459	59%	5.28	664 / 1118
adrenal gland	41%	139.60	107 / 258	28%	5.16	64 / 230
prostate	43%	111.04	105 / 245	24%	2.05	122 / 502
thymus	21%	35.58	138 / 653	41%	2.78	248 / 605
lymph node	0%	0	0 / 0	62%	11.09	18 / 29
skin	21%	38.42	376 / 1809	40%	9.45	190 / 472
liver	35%	67.81	78 / 226	13%	0.93	51 / 406
adipose	35%	536.42	423 / 1204	0%	0	0 / 0
blood vessel	30%	99.92	402 / 1335	0%	0	0 / 0
heart	23%	114.28	200 / 861	0%	0	0 / 0
muscle	1%	0.66	5 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007254	Biological process	JNK cascade
GO_0050796	Biological process	regulation of insulin secretion
GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_0006954	Biological process	inflammatory response
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0050999	Biological process	regulation of nitric-oxide synthase activity
GO_0035505	Biological process	positive regulation of myosin light chain kinase activity
GO_0046827	Biological process	positive regulation of protein export from nucleus
GO_0007267	Biological process	cell-cell signaling
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0006955	Biological process	immune response
GO_0033092	Biological process	positive regulation of immature T cell proliferation in thymus
GO_0032725	Biological process	positive regulation of granulocyte macrophage colony-stimulating factor production
GO_0097192	Biological process	extrinsic apoptotic signaling pathway in absence of ligand
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_0050767	Biological process	regulation of neurogenesis
GO_0030213	Biological process	hyaluronan biosynthetic process
GO_0035234	Biological process	ectopic germ cell programmed cell death
GO_0010573	Biological process	vascular endothelial growth factor production
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0051781	Biological process	positive regulation of cell division
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0031622	Biological process	positive regulation of fever generation
GO_0051044	Biological process	positive regulation of membrane protein ectodomain proteolysis
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0060252	Biological process	positive regulation of glial cell proliferation
GO_0048143	Biological process	astrocyte activation
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0030593	Biological process	neutrophil chemotaxis
GO_0031394	Biological process	positive regulation of prostaglandin biosynthetic process
GO_1900745	Biological process	positive regulation of p38MAPK cascade
GO_0050996	Biological process	positive regulation of lipid catabolic process
GO_0060559	Biological process	positive regulation of calcidiol 1-monooxygenase activity
GO_0030730	Biological process	sequestering of triglyceride
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0009743	Biological process	response to carbohydrate
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0032757	Biological process	positive regulation of interleukin-8 production
GO_0010829	Biological process	negative regulation of glucose transmembrane transport
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0032308	Biological process	positive regulation of prostaglandin secretion
GO_1903597	Biological process	negative regulation of gap junction assembly
GO_0070487	Biological process	monocyte aggregation
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0030949	Biological process	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO_0043122	Biological process	regulation of canonical NF-kappaB signal transduction
GO_0001660	Biological process	fever generation
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0007566	Biological process	embryo implantation
GO_0045833	Biological process	negative regulation of lipid metabolic process
GO_0060355	Biological process	positive regulation of cell adhesion molecule production
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0097398	Biological process	cellular response to interleukin-17
GO_0046627	Biological process	negative regulation of insulin receptor signaling pathway
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0032743	Biological process	positive regulation of interleukin-2 production
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0014805	Biological process	smooth muscle adaptation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0010575	Biological process	positive regulation of vascular endothelial growth factor production
GO_0071639	Biological process	positive regulation of monocyte chemotactic protein-1 production
GO_0034116	Biological process	positive regulation of heterotypic cell-cell adhesion
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0150078	Biological process	positive regulation of neuroinflammatory response
GO_0050691	Biological process	regulation of defense response to virus by host
GO_1903140	Biological process	regulation of establishment of endothelial barrier
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_2000556	Biological process	positive regulation of T-helper 1 cell cytokine production
GO_0045917	Biological process	positive regulation of complement activation
GO_0033198	Biological process	response to ATP
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0002711	Biological process	positive regulation of T cell mediated immunity
GO_0070498	Biological process	interleukin-1-mediated signaling pathway
GO_0050805	Biological process	negative regulation of synaptic transmission
GO_0070555	Biological process	response to interleukin-1
GO_0030335	Biological process	positive regulation of cell migration
GO_1902680	Biological process	positive regulation of RNA biosynthetic process
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0050995	Biological process	negative regulation of lipid catabolic process
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_0006915	Biological process	apoptotic process
GO_0032729	Biological process	positive regulation of type II interferon production
GO_2001240	Biological process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0050768	Biological process	negative regulation of neurogenesis
GO_0032496	Biological process	response to lipopolysaccharide
GO_0070164	Biological process	negative regulation of adiponectin secretion
GO_0005576	Cellular component	extracellular region
GO_0005615	Cellular component	extracellular space
GO_0005764	Cellular component	lysosome
GO_0030141	Cellular component	secretory granule
GO_0005829	Cellular component	cytosol
GO_0005149	Molecular function	interleukin-1 receptor binding
GO_0005125	Molecular function	cytokine activity
GO_0019904	Molecular function	protein domain specific binding
GO_0005515	Molecular function	protein binding
GO_0005178	Molecular function	integrin binding

IV. Literature review

[source]

Gene name	IL1B
Protein name	Interleukin-1 beta (IL-1 beta) (Catabolin) Multifunctional fusion protein [Includes: Interleukin-1; Interleukin-1 beta] Interleukin 1 beta Interleukin-1 beta
Synonyms	IL1F2 IL1b
Description	FUNCTION: Potent pro-inflammatory cytokine . Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production . Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells . Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 . Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore . Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection . . FUNCTION: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. . FUNCTION: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. .
Accessions	B5BUQ8 P01584 ENST00000263341.7 A0AA51YZX7 O43645 ENST00000416750.1 C9JSC2 C9JVK0 ENST00000432018.5 ENST00000418817.5 C9JWV2

IL1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review