CHI3L1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHI3L1 at tissue level.

III. Associated gene sets

GO_0030324Biological processlung development
GO_0006954Biological processinflammatory response
GO_0045766Biological processpositive regulation of angiogenesis
GO_0005975Biological processcarbohydrate metabolic process
GO_0070555Biological processresponse to interleukin-1
GO_0034612Biological processresponse to tumor necrosis factor
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0070741Biological processresponse to interleukin-6
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0006915Biological processapoptotic process
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007250Biological processactivation of NF-kappaB-inducing kinase activity
GO_0009612Biological processresponse to mechanical stimulus
GO_0006032Biological processchitin catabolic process
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0051216Biological processcartilage development
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0035580Cellular componentspecific granule lumen
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0031012Cellular componentextracellular matrix
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0030246Molecular functioncarbohydrate binding
GO_0004568Molecular functionchitinase activity
GO_0008061Molecular functionchitin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHI3L1
Protein nameCHI3L1 protein
Chitinase-3-like protein 1
Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)
Cartilage glycoprotein-39
Synonyms
DescriptionFUNCTION: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. .

AccessionsH0Y3U8
Q9NY39
Q9NY41
ENST00000255409.8
Q9NY40
P36222
ENST00000404436.2