IL23A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL23A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL23A at tissue level.

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0051135Biological processpositive regulation of NK T cell activation
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0010536Biological processpositive regulation of activation of Janus kinase activity
GO_0006954Biological processinflammatory response
GO_0042098Biological processT cell proliferation
GO_0043382Biological processpositive regulation of memory T cell differentiation
GO_0045087Biological processinnate immune response
GO_2000318Biological processpositive regulation of T-helper 17 type immune response
GO_0032819Biological processpositive regulation of natural killer cell proliferation
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0007165Biological processsignal transduction
GO_0051607Biological processdefense response to virus
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0034105Biological processpositive regulation of tissue remodeling
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0001916Biological processpositive regulation of T cell mediated cytotoxicity
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0048771Biological processtissue remodeling
GO_0032725Biological processpositive regulation of granulocyte macrophage colony-stimulating factor production
GO_0051142Biological processpositive regulation of NK T cell proliferation
GO_0032816Biological processpositive regulation of natural killer cell activation
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0032729Biological processpositive regulation of type II interferon production
GO_0050729Biological processpositive regulation of inflammatory response
GO_0002827Biological processpositive regulation of T-helper 1 type immune response
GO_2000330Biological processpositive regulation of T-helper 17 cell lineage commitment
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0042509Biological processregulation of tyrosine phosphorylation of STAT protein
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005576Cellular componentextracellular region
GO_0070743Cellular componentinterleukin-23 complex
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0045519Molecular functioninterleukin-23 receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL23A
Protein nameInterleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19)
SynonymsSGRF
UNQ2498/PRO5798
DescriptionFUNCTION: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity . Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 . This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A . In turn, participates in the early and effective intracellular bacterial clearance . Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells . .

AccessionsENST00000228534.6
Q9NPF7