HYAL3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of HYAL3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	223.49	245 / 245	99%	9.95	497 / 502
brain	99%	297.56	2603 / 2642	97%	6.03	684 / 705
breast	98%	120.15	451 / 459	96%	7.90	1078 / 1118
esophagus	100%	149.76	1440 / 1445	95%	6.02	173 / 183
uterus	97%	100.35	165 / 170	96%	7.46	442 / 459
intestine	98%	119.46	948 / 966	95%	7.40	500 / 527
stomach	100%	217.30	359 / 359	91%	6.05	260 / 286
ovary	91%	90.91	164 / 180	100%	12.03	428 / 430
lung	98%	139.30	569 / 578	92%	5.79	1057 / 1155
bladder	95%	121.67	20 / 21	95%	7.53	477 / 504
skin	98%	139.01	1778 / 1809	92%	6.32	432 / 472
liver	99%	166.71	224 / 226	88%	7.61	358 / 406
thymus	99%	120.44	647 / 653	86%	3.70	520 / 605
adrenal gland	100%	165.02	257 / 258	78%	4.82	179 / 230
pancreas	84%	59.14	274 / 328	92%	4.66	164 / 178
kidney	98%	109.28	87 / 89	61%	2.35	554 / 901
ureter	0%	0	0 / 0	100%	6.07	1 / 1
adipose	99%	119.20	1194 / 1204	0%	0	0 / 0
peripheral blood	97%	181.12	904 / 929	0%	0	0 / 0
spleen	97%	105.04	233 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	5.14	28 / 29
blood vessel	96%	104.83	1281 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	5.05	42 / 45
heart	87%	71.93	749 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	84%	3.47	67 / 80
muscle	34%	18.59	274 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006954	Biological process	inflammatory response
GO_0001552	Biological process	ovarian follicle atresia
GO_0009615	Biological process	response to virus
GO_0005975	Biological process	carbohydrate metabolic process
GO_0071347	Biological process	cellular response to interleukin-1
GO_0030214	Biological process	hyaluronan catabolic process
GO_0071493	Biological process	cellular response to UV-B
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0046677	Biological process	response to antibiotic
GO_2000355	Biological process	negative regulation of ovarian follicle development
GO_2000368	Biological process	positive regulation of acrosomal vesicle exocytosis
GO_0051216	Biological process	cartilage development
GO_0007341	Biological process	penetration of zona pellucida
GO_0001669	Cellular component	acrosomal vesicle
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005769	Cellular component	early endosome
GO_0002080	Cellular component	acrosomal membrane
GO_0005764	Cellular component	lysosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0097225	Cellular component	sperm midpiece
GO_0004415	Molecular function	hyalurononglucosaminidase activity
GO_0033906	Molecular function	hyaluronoglucuronidase activity
GO_0001618	Molecular function	virus receptor activity
GO_0005515	Molecular function	protein binding

Gene name	HYAL3
Protein name	Hyaluronidase (EC 3.2.1.35) Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3) HYAL3 protein (N-acetyltransferase 6, isoform CRA_a) (cDNA, FLJ94421, Homo sapiens putative tumor suppressor (FUS2), mRNA)
Synonyms	LUCA3 hCG_2039743 NAT6
Description	FUNCTION: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. .
Accessions	ENST00000415204.5 [O43820-3] ENST00000450982.6 [O43820-2] O43820 ENST00000435141.1 ENST00000359051.7 [O43820-2] ENST00000513170.1 [O43820-4] C9JB51 ENST00000336307.6 [O43820-1] Q6IAP1 ENST00000621157.5 [O43820-1]

HYAL3 report