AZU1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AZU1 at tissue level.

III. Associated gene sets

GO_0050766Biological processpositive regulation of phagocytosis
GO_0042117Biological processmonocyte activation
GO_0006954Biological processinflammatory response
GO_0045123Biological processcellular extravasation
GO_0001774Biological processmicroglial cell activation
GO_0045348Biological processpositive regulation of MHC class II biosynthetic process
GO_0043114Biological processregulation of vascular permeability
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0051607Biological processdefense response to virus
GO_0010628Biological processpositive regulation of gene expression
GO_0035696Biological processmonocyte extravasation
GO_0045785Biological processpositive regulation of cell adhesion
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0019730Biological processantimicrobial humoral response
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006508Biological processproteolysis
GO_0008347Biological processglial cell migration
GO_0070944Biological processneutrophil-mediated killing of bacterium
GO_0070528Biological processprotein kinase C signaling
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0032724Biological processpositive regulation of fractalkine production
GO_0050930Biological processinduction of positive chemotaxis
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0060326Biological processcell chemotaxis
GO_0048246Biological processmacrophage chemotaxis
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0035578Cellular componentazurophil granule lumen
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0042582Cellular componentazurophil granule
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0008201Molecular functionheparin binding
GO_0008233Molecular functionpeptidase activity
GO_0015643Molecular functiontoxic substance binding
GO_0043395Molecular functionheparan sulfate proteoglycan binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameAZU1
Protein nameAzurocidin
AZU1 protein
Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP) (hHBP)
Synonyms
DescriptionFUNCTION: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. .

AccessionsENST00000633060.1
ENST00000592205.5
ENST00000233997.4
A0A087WXP0
ENST00000620695.2
Q86SR2
P20160