LGALS9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001190Biological processpositive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO_0043305Biological processnegative regulation of mast cell degranulation
GO_0071636Biological processpositive regulation of transforming growth factor beta production
GO_0070241Biological processpositive regulation of activated T cell autonomous cell death
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0006954Biological processinflammatory response
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0010629Biological processnegative regulation of gene expression
GO_0032834Biological processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
GO_0032673Biological processregulation of interleukin-4 production
GO_0032736Biological processpositive regulation of interleukin-13 production
GO_0010628Biological processpositive regulation of gene expression
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0002519Biological processnatural killer cell tolerance induction
GO_2000670Biological processpositive regulation of dendritic cell apoptotic process
GO_0097029Biological processmature conventional dendritic cell differentiation
GO_0046598Biological processpositive regulation of viral entry into host cell
GO_0006935Biological processchemotaxis
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0070555Biological processresponse to interleukin-1
GO_0007565Biological processfemale pregnancy
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0098586Biological processcellular response to virus
GO_2000510Biological processpositive regulation of dendritic cell chemotaxis
GO_0045953Biological processnegative regulation of natural killer cell mediated cytotoxicity
GO_0070371Biological processERK1 and ERK2 cascade
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_2000563Biological processpositive regulation of CD4-positive, alpha-beta T cell proliferation
GO_2001269Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_1900744Biological processregulation of p38MAPK cascade
GO_2001200Biological processpositive regulation of dendritic cell differentiation
GO_0071639Biological processpositive regulation of monocyte chemotactic protein-1 production
GO_0032682Biological processnegative regulation of chemokine production
GO_0032689Biological processnegative regulation of type II interferon production
GO_0032729Biological processpositive regulation of type II interferon production
GO_2000562Biological processnegative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0034134Biological processtoll-like receptor 2 signaling pathway
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0038066Biological processp38MAPK cascade
GO_0032674Biological processregulation of interleukin-5 production
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032496Biological processresponse to lipopolysaccharide
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0071346Biological processcellular response to type II interferon
GO_0005615Cellular componentextracellular space
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0030246Molecular functioncarbohydrate binding
GO_0016936Molecular functiongalactoside binding
GO_0048030Molecular functiondisaccharide binding
GO_0005534Molecular functiongalactose binding

IV. Literature review

[source]
Gene nameLGALS9
Protein nameGalectin 9
Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)
Galectin
Synonyms
DescriptionFUNCTION: Binds galactosides . Has high affinity for the Forssman pentasaccharide . Ligand for HAVCR2/TIM3 . Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death . Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration . Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation . Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection . Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells . Inhibits degranulation and induces apoptosis of mast cells . Induces maturation and migration of dendritic cells . Inhibits natural killer (NK) cell function . Can transform NK cell phenotype from peripheral to decidual during pregnancy . Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity). .; FUNCTION: [Isoform 2]: Acts as an eosinophil chemoattractant . It also inhibits angiogenesis . Suppresses IFNG production by natural killer cells (By similarity). .

AccessionsENST00000302228.9 [O00182-2]
J3QKK6
ENST00000580779.5
ENST00000577392.5
J3QS92
ENST00000578944.1
J3KS82
ENST00000395473.7 [O00182-1]
J3KSA0
ENST00000467111.5
O00182
ENST00000581710.5
ENST00000313648.10 [O00182-4]
K7EPS0
ENST00000584661.5