UMOD | OmnibusX

Name	Number of supported studies	Average coverage
kidney loop of Henle epithelial cell	8 studies	60% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
kidney	4 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	79072.74	89 / 89	19%	17.77	169 / 901
pancreas	100%	333.14	328 / 328	7%	0.11	12 / 178
stomach	60%	19.94	214 / 359	2%	0.08	6 / 286
breast	33%	14.08	152 / 459	12%	0.30	139 / 1118
prostate	32%	6.38	79 / 245	4%	0.07	20 / 502
bladder	19%	5.33	4 / 21	0%	0.01	1 / 504
thymus	5%	1.65	33 / 653	3%	0.13	16 / 605
adipose	5%	5.72	55 / 1204	0%	0	0 / 0
esophagus	4%	1.22	52 / 1445	1%	0.01	1 / 183
intestine	4%	0.88	36 / 966	0%	0.02	2 / 527
lung	3%	0.59	17 / 578	1%	0.05	12 / 1155
ovary	4%	0.58	7 / 180	0%	0	0 / 430
adrenal gland	4%	0.63	10 / 258	0%	0	0 / 230
spleen	4%	0.54	9 / 241	0%	0	0 / 0
uterus	3%	0.48	5 / 170	1%	0.03	3 / 459
skin	3%	0.87	46 / 1809	1%	0.01	3 / 472
heart	3%	0.52	27 / 861	0%	0	0 / 0
muscle	3%	0.63	23 / 803	0%	0	0 / 0
blood vessel	3%	0.80	35 / 1335	0%	0	0 / 0
liver	2%	0.50	5 / 226	0%	0	0 / 406
brain	2%	0.67	42 / 2642	0%	0.00	1 / 705
peripheral blood	1%	0.20	11 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1990266	Biological process	neutrophil migration
GO_0070294	Biological process	renal sodium ion absorption
GO_0097190	Biological process	apoptotic signaling pathway
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0071918	Biological process	urea transmembrane transport
GO_0034620	Biological process	cellular response to unfolded protein
GO_0009414	Biological process	response to water deprivation
GO_0046720	Biological process	citric acid secretion
GO_0072233	Biological process	metanephric thick ascending limb development
GO_0006954	Biological process	inflammatory response
GO_0003091	Biological process	renal water homeostasis
GO_0003094	Biological process	glomerular filtration
GO_0061077	Biological process	chaperone-mediated protein folding
GO_0030643	Biological process	intracellular phosphate ion homeostasis
GO_0035809	Biological process	regulation of urine volume
GO_0060073	Biological process	micturition
GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_0007029	Biological process	endoplasmic reticulum organization
GO_0008217	Biological process	regulation of blood pressure
GO_0072051	Biological process	juxtaglomerular apparatus development
GO_0072665	Biological process	protein localization to vacuole
GO_0072221	Biological process	metanephric distal convoluted tubule development
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0015747	Biological process	urate transport
GO_0097744	Biological process	renal urate salt excretion
GO_0006968	Biological process	cellular defense response
GO_0006883	Biological process	intracellular sodium ion homeostasis
GO_0055075	Biological process	potassium ion homeostasis
GO_0051223	Biological process	regulation of protein transport
GO_0002251	Biological process	organ or tissue specific immune response
GO_0140367	Biological process	antibacterial innate immune response
GO_0072218	Biological process	metanephric ascending thin limb development
GO_0008380	Biological process	RNA splicing
GO_0033555	Biological process	multicellular organismal response to stress
GO_0072044	Biological process	collecting duct development
GO_0030644	Biological process	intracellular chloride ion homeostasis
GO_0006914	Biological process	autophagy
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0097709	Biological process	connective tissue replacement
GO_0006629	Biological process	lipid metabolic process
GO_0044861	Biological process	protein transport into plasma membrane raft
GO_0007157	Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0036503	Biological process	ERAD pathway
GO_0033209	Biological process	tumor necrosis factor-mediated signaling pathway
GO_0032496	Biological process	response to lipopolysaccharide
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0016324	Cellular component	apical plasma membrane
GO_0005615	Cellular component	extracellular space
GO_0000922	Cellular component	spindle pole
GO_0016020	Cellular component	membrane
GO_0005796	Cellular component	Golgi lumen
GO_0070062	Cellular component	extracellular exosome
GO_0019898	Cellular component	extrinsic component of membrane
GO_0060170	Cellular component	ciliary membrane
GO_0009986	Cellular component	cell surface
GO_0005929	Cellular component	cilium
GO_0005783	Cellular component	endoplasmic reticulum
GO_0098552	Cellular component	side of membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0019864	Molecular function	IgG binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	UMOD
Protein name	Uromodulin Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]
Synonyms
Description	FUNCTION: [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF . Facilitates neutrophil migration across renal epithelia . .; FUNCTION: [Uromodulin, secreted form]: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals (By similarity). Protects against urinary tract infections by binding to type 1 fimbriated E.coli . Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation . Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens . .
Accessions	I3L3Z4 ENST00000576546.1 ENST00000570757.5 ENST00000573567.5 A0A481NSA0 ENST00000577168.2 I3L1M3 I3L2K2 ENST00000571174.5 I3L4Y6 P07911 ENST00000396134.6 [P07911-5] ENST00000574195.5 ENST00000396138.9 [P07911-1] X6RBG4 I3L3E0 I3L4B0 ENST00000576688.2 Q8NHW8 ENST00000396138 ENST00000570972.2 I3L2J2 ENST00000570689.5 [P07911-1] A0A481NSQ2

UMOD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review