NLRP10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NLRP10 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP10 at tissue level.

III. Associated gene sets

GO_0050832Biological processdefense response to fungus
GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_2000318Biological processpositive regulation of T-helper 17 type immune response
GO_0002250Biological processadaptive immune response
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0002218Biological processactivation of innate immune response
GO_0050729Biological processpositive regulation of inflammatory response
GO_0002827Biological processpositive regulation of T-helper 1 type immune response
GO_0032730Biological processpositive regulation of interleukin-1 alpha production
GO_1900426Biological processpositive regulation of defense response to bacterium
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0005524Molecular functionATP binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameNLRP10
Protein nameNACHT, LRR and PYD domains-containing protein 10 (Nucleotide-binding oligomerization domain protein 8)
NACHT, LRR and PYD domains-containing protein 10
SynonymsPYNOD
NALP10
NOD8
DescriptionFUNCTION: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID . Displays anti-inflammatory activity . Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection . Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens . Exhibits both ATPase and GTPase activities . .

AccessionsENST00000625936.1
ENST00000625327.2
ENST00000691676.1
E9PPY0
ENST00000629228.1
Q86W26
ENST00000612291.2
ENST00000328600.3