Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasmacytoid dendritic cell | 27 studies | 83% ± 16% | |
conventional dendritic cell | 22 studies | 34% ± 13% | |
macrophage | 11 studies | 40% ± 18% | |
B cell | 10 studies | 30% ± 12% | |
dendritic cell | 7 studies | 55% ± 18% | |
memory B cell | 7 studies | 21% ± 4% | |
myeloid cell | 6 studies | 34% ± 18% | |
immature B cell | 5 studies | 39% ± 23% | |
microglial cell | 5 studies | 37% ± 20% | |
non-classical monocyte | 4 studies | 32% ± 17% | |
monocyte | 4 studies | 26% ± 6% | |
naive B cell | 4 studies | 27% ± 10% | |
precursor B cell | 4 studies | 37% ± 23% | |
leukocyte | 3 studies | 31% ± 11% |
Insufficient scRNA-seq data for expression of PLD4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 97% | 419.22 | 2550 / 2642 | 98% | 33.26 | 689 / 705 |
prostate | 90% | 147.94 | 220 / 245 | 82% | 5.15 | 414 / 502 |
thymus | 70% | 77.02 | 456 / 653 | 88% | 7.87 | 531 / 605 |
breast | 50% | 76.86 | 228 / 459 | 82% | 9.18 | 916 / 1118 |
kidney | 38% | 42.73 | 34 / 89 | 90% | 11.42 | 811 / 901 |
uterus | 80% | 79.16 | 136 / 170 | 46% | 2.75 | 212 / 459 |
lung | 57% | 66.53 | 328 / 578 | 59% | 4.41 | 687 / 1155 |
ovary | 36% | 23.36 | 65 / 180 | 74% | 7.72 | 319 / 430 |
pancreas | 21% | 17.82 | 69 / 328 | 80% | 6.36 | 143 / 178 |
spleen | 100% | 916.27 | 241 / 241 | 0% | 0 | 0 / 0 |
skin | 30% | 21.74 | 547 / 1809 | 59% | 4.97 | 277 / 472 |
bladder | 57% | 55.29 | 12 / 21 | 30% | 1.79 | 150 / 504 |
intestine | 54% | 144.29 | 521 / 966 | 33% | 1.66 | 172 / 527 |
peripheral blood | 79% | 431.38 | 738 / 929 | 0% | 0 | 0 / 0 |
adrenal gland | 26% | 24.03 | 67 / 258 | 53% | 2.94 | 122 / 230 |
lymph node | 0% | 0 | 0 / 0 | 72% | 16.17 | 21 / 29 |
stomach | 29% | 21.26 | 105 / 359 | 42% | 3.34 | 120 / 286 |
esophagus | 39% | 30.24 | 565 / 1445 | 30% | 1.59 | 54 / 183 |
tonsil | 0% | 0 | 0 / 0 | 67% | 5.52 | 30 / 45 |
blood vessel | 63% | 75.87 | 841 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 38% | 1.85 | 30 / 80 |
liver | 4% | 3.84 | 9 / 226 | 24% | 1.65 | 97 / 406 |
adipose | 24% | 19.55 | 284 / 1204 | 0% | 0 | 0 / 0 |
heart | 6% | 4.00 | 49 / 861 | 0% | 0 | 0 / 0 |
muscle | 0% | 0.23 | 4 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0002244 | Biological process | hematopoietic progenitor cell differentiation |
GO_1900015 | Biological process | regulation of cytokine production involved in inflammatory response |
GO_0006259 | Biological process | DNA metabolic process |
GO_0006954 | Biological process | inflammatory response |
GO_0051649 | Biological process | establishment of localization in cell |
GO_0006909 | Biological process | phagocytosis |
GO_0045087 | Biological process | innate immune response |
GO_0032588 | Cellular component | trans-Golgi network membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0045335 | Cellular component | phagocytic vesicle |
GO_0005769 | Cellular component | early endosome |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005634 | Cellular component | nucleus |
GO_0045145 | Molecular function | single-stranded DNA 5'-3' DNA exonuclease activity |
GO_0004630 | Molecular function | phospholipase D activity |
Gene name | PLD4 |
Protein name | 5'-3' exonuclease PLD4 (EC 3.1.16.1) (Choline phosphatase 4) (Phosphatidylcholine-hydrolyzing phospholipase D4) (Phospholipase D family member 4) (Phospholipase D4) (PLD 4) Phospholipase D family member 4 |
Synonyms | UNQ2488/PRO5775 C14orf175 |
Description | FUNCTION: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. . |
Accessions | ENST00000392593.9 Q96BZ4 ENST00000553861.1 F5H2B5 A0A3B3IT68 ENST00000649344.1 G3V3J8 G3V472 ENST00000540372.5 ENST00000557573.1 |