PLD4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLD4 at tissue level.

III. Associated gene sets

GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_1900015Biological processregulation of cytokine production involved in inflammatory response
GO_0006259Biological processDNA metabolic process
GO_0006954Biological processinflammatory response
GO_0051649Biological processestablishment of localization in cell
GO_0006909Biological processphagocytosis
GO_0045087Biological processinnate immune response
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0045335Cellular componentphagocytic vesicle
GO_0005769Cellular componentearly endosome
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0045145Molecular functionsingle-stranded DNA 5'-3' DNA exonuclease activity
GO_0004630Molecular functionphospholipase D activity

IV. Literature review

[source]
Gene namePLD4
Protein name5'-3' exonuclease PLD4 (EC 3.1.16.1) (Choline phosphatase 4) (Phosphatidylcholine-hydrolyzing phospholipase D4) (Phospholipase D family member 4) (Phospholipase D4) (PLD 4)
Phospholipase D family member 4
SynonymsUNQ2488/PRO5775
C14orf175
DescriptionFUNCTION: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. .

AccessionsENST00000392593.9
Q96BZ4
ENST00000553861.1
F5H2B5
A0A3B3IT68
ENST00000649344.1
G3V3J8
G3V472
ENST00000540372.5
ENST00000557573.1