IL5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL5 at tissue level.

III. Associated gene sets

GO_0071803Biological processpositive regulation of podosome assembly
GO_0006955Biological processimmune response
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006954Biological processinflammatory response
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0045645Biological processpositive regulation of eosinophil differentiation
GO_0038043Biological processinterleukin-5-mediated signaling pathway
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005137Molecular functioninterleukin-5 receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity
GO_0008083Molecular functiongrowth factor activity

IV. Literature review

[source]
Gene nameIL5
Protein nameInterleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)
Interleukin-5 (Eosinophil differentiation factor)
Synonyms
DescriptionFUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils . Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB . Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively . .

FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. .

AccessionsC9JQP9
ENST00000231454.6
P05113
ENST00000450655.1