CUL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_0016567Biological processprotein ubiquitination
GO_0001831Biological processtrophectodermal cellular morphogenesis
GO_0006954Biological processinflammatory response
GO_0000209Biological processprotein polyubiquitination
GO_0045842Biological processpositive regulation of mitotic metaphase/anaphase transition
GO_0051865Biological processprotein autoubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0017145Biological processstem cell division
GO_0140252Biological processregulation protein catabolic process at postsynapse
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007369Biological processgastrulation
GO_0048208Biological processCOPII vesicle coating
GO_0030030Biological processcell projection organization
GO_0031648Biological processprotein destabilization
GO_0032480Biological processnegative regulation of type I interferon production
GO_1901992Biological processpositive regulation of mitotic cell cycle phase transition
GO_0031145Biological processanaphase-promoting complex-dependent catabolic process
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0071630Biological processnuclear protein quality control by the ubiquitin-proteasome system
GO_0071230Biological processcellular response to amino acid stimulus
GO_0072576Biological processliver morphogenesis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0040016Biological processembryonic cleavage
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0010467Biological processgene expression
GO_0043149Biological processstress fiber assembly
GO_0016055Biological processWnt signaling pathway
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0006513Biological processprotein monoubiquitination
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0044346Biological processfibroblast apoptotic process
GO_1900076Biological processregulation of cellular response to insulin stimulus
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0032467Biological processpositive regulation of cytokinesis
GO_0016477Biological processcell migration
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0098978Cellular componentglutamatergic synapse
GO_0036126Cellular componentsperm flagellum
GO_0005886Cellular componentplasma membrane
GO_0000922Cellular componentspindle pole
GO_0072686Cellular componentmitotic spindle
GO_0016020Cellular componentmembrane
GO_0005827Cellular componentpolar microtubule
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005794Cellular componentGolgi apparatus
GO_0098794Cellular componentpostsynapse
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0160072Molecular functionubiquitin ligase complex scaffold activity
GO_0005112Molecular functionNotch binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0031208Molecular functionPOZ domain binding
GO_0030332Molecular functioncyclin binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCUL3
Protein nameCullin 3
Uncharacterized protein CUL3
Cullin-3 (CUL-3)
SynonymsKIAA0617
DescriptionFUNCTION: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins . As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) . BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 . The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination . The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB . The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation . The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway . The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) . The BCR(KLHL25) ubiquitin ligase complex is also involved in lipid synthesis by mediating ubiquitination and degradation of ACLY . The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification . Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 . In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis . The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity . The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry . The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes . As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1 . By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation . .

AccessionsENST00000409096.5 [Q13618-2]
A0A087X1R9
ENST00000454323.1
H7C1L6
H7C399
H7C1J0
ENST00000264414.9 [Q13618-1]
Q13618
ENST00000409777.5 [Q13618-2]
ENST00000436172.1
ENST00000451538.1
Q53RD1
ENST00000344951.8 [Q13618-3]
ENST00000432260.2
Q53S54