I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 6 studies | 22% ± 6% | |
| myeloid cell | 3 studies | 21% ± 5% | |
| microglial cell | 3 studies | 27% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 6 studies | 22% ± 6% | |
| myeloid cell | 3 studies | 21% ± 5% | |
| microglial cell | 3 studies | 27% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 955.99 | 226 / 226 | 97% | 18.80 | 395 / 406 |
| bladder | 100% | 1257.24 | 21 / 21 | 96% | 26.12 | 482 / 504 |
| lung | 100% | 1676.28 | 577 / 578 | 95% | 13.54 | 1096 / 1155 |
| intestine | 97% | 460.49 | 935 / 966 | 95% | 15.66 | 503 / 527 |
| thymus | 100% | 569.51 | 651 / 653 | 91% | 13.12 | 550 / 605 |
| esophagus | 91% | 533.42 | 1313 / 1445 | 94% | 22.37 | 172 / 183 |
| kidney | 99% | 530.55 | 88 / 89 | 84% | 9.28 | 754 / 901 |
| prostate | 100% | 599.42 | 245 / 245 | 81% | 5.42 | 408 / 502 |
| stomach | 81% | 274.55 | 290 / 359 | 97% | 18.45 | 277 / 286 |
| uterus | 95% | 307.65 | 162 / 170 | 81% | 13.60 | 372 / 459 |
| breast | 100% | 798.89 | 459 / 459 | 73% | 5.41 | 815 / 1118 |
| brain | 88% | 355.07 | 2334 / 2642 | 76% | 7.24 | 536 / 705 |
| skin | 99% | 694.30 | 1789 / 1809 | 56% | 4.43 | 262 / 472 |
| pancreas | 56% | 162.93 | 183 / 328 | 96% | 22.29 | 171 / 178 |
| adrenal gland | 100% | 547.60 | 258 / 258 | 48% | 3.05 | 111 / 230 |
| ovary | 63% | 137.99 | 114 / 180 | 60% | 5.44 | 259 / 430 |
| adipose | 100% | 965.50 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 753.20 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.69 | 1 / 1 |
| muscle | 100% | 1694.49 | 801 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 97% | 486.72 | 1291 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 23.26 | 42 / 45 |
| peripheral blood | 91% | 607.15 | 841 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 83% | 10.54 | 24 / 29 |
| heart | 63% | 172.07 | 541 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.12 | 3 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002755 | Biological process | MyD88-dependent toll-like receptor signaling pathway |
| GO_0031663 | Biological process | lipopolysaccharide-mediated signaling pathway |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007249 | Biological process | canonical NF-kappaB signal transduction |
| GO_0001959 | Biological process | regulation of cytokine-mediated signaling pathway |
| GO_0070498 | Biological process | interleukin-1-mediated signaling pathway |
| GO_0070555 | Biological process | response to interleukin-1 |
| GO_0032088 | Biological process | negative regulation of NF-kappaB transcription factor activity |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0034142 | Biological process | toll-like receptor 4 signaling pathway |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0008063 | Biological process | Toll signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0035591 | Molecular function | signaling adaptor activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IRAK2 |
| Protein name | Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) |
| Synonyms | |
| Description | FUNCTION: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. . |
| Accessions | O43187 ENST00000256458.5 |
