NLRP9 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NLRP9 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP9 at tissue level.

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0070269Biological processpyroptotic inflammatory response
GO_0032741Biological processpositive regulation of interleukin-18 production
GO_0006954Biological processinflammatory response
GO_0050727Biological processregulation of inflammatory response
GO_0045087Biological processinnate immune response
GO_0061702Cellular componentcanonical inflammasome complex
GO_0005737Cellular componentcytoplasm
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNLRP9
Protein nameNACHT, LRR and PYD domains-containing protein 9 (Nucleotide-binding oligomerization domain protein 6) (PYRIN and NACHT-containing protein 12)
SynonymsPAN12
NOD6
NALP9
DescriptionFUNCTION: As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments. .

AccessionsENST00000332836.7 [Q7RTR0-1]
Q7RTR0
ENST00000590200.1 [Q7RTR0-2]